0 10

Cited 0 times in

Differential regulation by Seogak Jihwang-Tang on cytokines production in peripheral blood mononuclear cells from the cerebral infarction patients presenting with altered consciousness

Authors
 Hyun-Ja Jeong  ;  Hwan-Suck Chung  ;  Yo-Han Kim  ;  Byung-Soon Moon  ;  Kang-Keyng Sung  ;  Sun-Joon Bai  ;  Kwang-Ho Cho  ;  Yun-Kyung Kim  ;  Seung-Heon Hong  ;  Taekyun Shin  ;  Hyung-Min Kim 
Citation
 JOURNAL OF ETHNOPHARMACOLOGY, Vol.94(2-3) : 289-294, 2004-10 
Journal Title
 JOURNAL OF ETHNOPHARMACOLOGY 
ISSN
 0378-8741 
Issue Date
2004-10
MeSH
Cells, Cultured ; Cerebral Infarction / blood* ; Cerebral Infarction / drug therapy ; Consciousness Disorders / blood* ; Cytokines / biosynthesis* ; Dose-Response Relationship, Drug ; Humans ; Leukocytes, Mononuclear / drug effects* ; Leukocytes, Mononuclear / metabolism ; Medicine, East Asian Traditional ; Plant Extracts / isolation & purification ; Plant Extracts / pharmacology ; Plant Extracts / therapeutic use ; Plants, Medicinal* ; Statistics, Nonparametric
Abstract
Seogak Jihwang-Tang (SJT) has been widely used to treat patients suffering from cerebral infarction. However, very little scientific investigation has been carried out. We investigated the effect of SJT on the production of various cytokines using peripheral blood mononuclear cells from the cerebral infarction patients presenting with altered consciousness. The cytokines production was determined by enzyme-linked immunosorbent assay. The amount of IL-4, IL-10 and TGF-beta1 in culture supernatant significantly increased in the SJT, lipopolysaccharide (LPS) or PHA-treated cells compared to unstimulated cells (P < 0.05). We also showed that increased IL-4 and IL-10 levels by LPS or phytohaemagglutinin (PHA) were significantly inhibited by SJT in a dose-dependent manner. Maximal inhibition rate of IL-4 and IL-10 production by SJT was 45.6 +/- 3.3% and 61 +/- 4.7% for LPS-stimulated cells and 27.3 +/- 1.2% and 83.6 +/- 2% for PHA-stimulated cells, respectively (P < 0.05). On the other hand, SJT significantly increased the LPS or PHA-induced TGF-beta1 production (P < 0.05). These data suggest that SJT has a regulatory effect on the cytokines production, which might explain its beneficial effect in the treatment of cerebral infarction.
Full Text
https://www.sciencedirect.com/science/article/pii/S0378874104002569
DOI
10.1016/j.jep.2004.05.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178798
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links