Cited 8 times in
Differential regulation by Seogak Jihwang-Tang on cytokines production in peripheral blood mononuclear cells from the cerebral infarction patients presenting with altered consciousness
DC Field | Value | Language |
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dc.contributor.author | 배선준 | - |
dc.date.accessioned | 2020-09-04T02:05:32Z | - |
dc.date.available | 2020-09-04T02:05:32Z | - |
dc.date.issued | 2004-10 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178798 | - |
dc.description.abstract | Seogak Jihwang-Tang (SJT) has been widely used to treat patients suffering from cerebral infarction. However, very little scientific investigation has been carried out. We investigated the effect of SJT on the production of various cytokines using peripheral blood mononuclear cells from the cerebral infarction patients presenting with altered consciousness. The cytokines production was determined by enzyme-linked immunosorbent assay. The amount of IL-4, IL-10 and TGF-beta1 in culture supernatant significantly increased in the SJT, lipopolysaccharide (LPS) or PHA-treated cells compared to unstimulated cells (P < 0.05). We also showed that increased IL-4 and IL-10 levels by LPS or phytohaemagglutinin (PHA) were significantly inhibited by SJT in a dose-dependent manner. Maximal inhibition rate of IL-4 and IL-10 production by SJT was 45.6 +/- 3.3% and 61 +/- 4.7% for LPS-stimulated cells and 27.3 +/- 1.2% and 83.6 +/- 2% for PHA-stimulated cells, respectively (P < 0.05). On the other hand, SJT significantly increased the LPS or PHA-induced TGF-beta1 production (P < 0.05). These data suggest that SJT has a regulatory effect on the cytokines production, which might explain its beneficial effect in the treatment of cerebral infarction. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Sequoia | - |
dc.relation.isPartOf | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Cerebral Infarction / blood* | - |
dc.subject.MESH | Cerebral Infarction / drug therapy | - |
dc.subject.MESH | Consciousness Disorders / blood* | - |
dc.subject.MESH | Cytokines / biosynthesis* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukocytes, Mononuclear / drug effects* | - |
dc.subject.MESH | Leukocytes, Mononuclear / metabolism | - |
dc.subject.MESH | Medicine, East Asian Traditional | - |
dc.subject.MESH | Plant Extracts / isolation & purification | - |
dc.subject.MESH | Plant Extracts / pharmacology | - |
dc.subject.MESH | Plant Extracts / therapeutic use | - |
dc.subject.MESH | Plants, Medicinal* | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.title | Differential regulation by Seogak Jihwang-Tang on cytokines production in peripheral blood mononuclear cells from the cerebral infarction patients presenting with altered consciousness | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Hyun-Ja Jeong | - |
dc.contributor.googleauthor | Hwan-Suck Chung | - |
dc.contributor.googleauthor | Yo-Han Kim | - |
dc.contributor.googleauthor | Byung-Soon Moon | - |
dc.contributor.googleauthor | Kang-Keyng Sung | - |
dc.contributor.googleauthor | Sun-Joon Bai | - |
dc.contributor.googleauthor | Kwang-Ho Cho | - |
dc.contributor.googleauthor | Yun-Kyung Kim | - |
dc.contributor.googleauthor | Seung-Heon Hong | - |
dc.contributor.googleauthor | Taekyun Shin | - |
dc.contributor.googleauthor | Hyung-Min Kim | - |
dc.identifier.doi | 10.1016/j.jep.2004.05.014 | - |
dc.contributor.localId | A01795 | - |
dc.relation.journalcode | J01406 | - |
dc.identifier.eissn | 1872-7573 | - |
dc.identifier.pmid | 15325733 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0378874104002569 | - |
dc.contributor.alternativeName | Bai, Sun Joon | - |
dc.contributor.affiliatedAuthor | 배선준 | - |
dc.citation.volume | 94 | - |
dc.citation.number | 2-3 | - |
dc.citation.startPage | 289 | - |
dc.citation.endPage | 294 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, Vol.94(2-3) : 289-294, 2004-10 | - |
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