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Vestibular imbalance associated with a lesion in the nucleus prepositus hypoglossi area

Authors
 Sang Won Seo  ;  Ha Young Shin  ;  Seo Hyun Kim  ;  Sang Won Han  ;  Kyung Yul Lee  ;  Seung Min Kim  ;  Ji Hoe Heo 
Citation
 ARCHIVES OF NEUROLOGY, Vol.61(9) : 1440-1443, 2004-09 
Journal Title
 ARCHIVES OF NEUROLOGY 
ISSN
 0003-9942 
Issue Date
2004-09
MeSH
Aged ; Aged, 80 and over ; Ataxia / etiology ; Brain Infarction / complications* ; Brain Infarction / diagnostic imaging ; Brain Infarction / physiopathology* ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Medulla Oblongata / diagnostic imaging ; Medulla Oblongata / pathology* ; Middle Aged ; Neural Pathways / physiology ; Nystagmus, Pathologic / etiology ; Radiography ; Vertigo / etiology ; Vestibular Diseases / etiology* ; Vestibular Nuclei / diagnostic imaging ; Vestibular Nuclei / pathology
Abstract
Background: The nucleus prepositus hypoglossi (NPH) is known to be a neural integrator of horizontal eye movements. Although the role of the human NPH is not well known, it may also function in postural balance, in view of its anatomic connections with the vestibular nuclei and vestibulocerebellum and of lesion studies in experimental animals. Objective: To show that the human NPH contributes to vestibular function in addition to eye movement control. Design: Case series. Setting: University hospital. Patients Six patients with small and discrete brainstem infarctions that predominantly involved the NPH region.Main Outcome Measure Findings on magnetic resonance images. Results: The NPH was affected at the lower pontine level in 2 patients and at the upper medullary level in 4. In addition to gaze-evoked nystagmus, all patients had vertigo, vomiting, and postural ataxia, suggesting vestibular dysfunction. The patients typically fell contralaterally or bilaterally to the lesion side. Conclusion: The NPH serves a vestibular function in addition to its oculomotor control function.
Full Text
https://jamanetwork.com/journals/jamaneurology/fullarticle/786596
DOI
10.1001/archneur.61.9.1440
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Min(김승민) ORCID logo https://orcid.org/0000-0002-4384-9640
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Han, Sang Won(한상원)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178779
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