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한국인 원인 불명 조기폐경 환자의 FMR1 유전자 양상

Other Titles
 Fragile X Premutation in Patients with Idiopathic Premature Ovarian Failure 
Authors
 허창영  ;  최영민  ;  박성효  ;  윤병구  ;  이규섭  ;  나용진  ;  이병석  ;  류철희  ;  이화진  ;  설혜원  ;  오선경 
Citation
 Korean Journal of Gynecologic Endoscopy and Minimally Invasive Surgery (대한산부인과내시경학회잡지), Vol.46(5) : 978-983, 2003-05 
Journal Title
 Korean Journal of Gynecologic Endoscopy and Minimally Invasive Surgery (대한산부인과내시경학회잡지) 
ISSN
 1229-3849 
Issue Date
2003-05
Keywords
Premature ovarian failure ; Fragile X syndrome ; Premutation ; Carrier
Abstract
Objective : To explore the incidence of fragile X premutation in patients with idiopathic premature ovarian failure, particularly in the Korean population. Design : A prospective study. Materials and Methods : Eighty-three women affected by idiopathic premature ovarian failure were recruited for this study. Patient with known causes of premature ovarian failure were excluded : cytogenetic abnormalities, prior chemotherapy, prior bilateral oophorectomy. DNA was extracted from peripheral blood. Fragile X (FRAXA) premutation was evaluated by PCR amplification of and Southern blot analysis for FMR1 gene. Results : The FRAXA premutation was detected in three (3.6%) out of 83 patients with idiopathic premature ovarian failure. Conclusion : This result suggests that fragile X premutation screening is indicated in patients with idiopathic premature ovarian failure, particularly in the Korean population.
Full Text
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2117732
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178770
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