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한국인 원인 불명 조기폐경 환자의 FMR1 유전자 양상
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이병석 | - |
dc.date.accessioned | 2020-09-04T02:02:41Z | - |
dc.date.available | 2020-09-04T02:02:41Z | - |
dc.date.issued | 2003-05 | - |
dc.identifier.issn | 1229-3849 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178770 | - |
dc.description.abstract | Objective : To explore the incidence of fragile X premutation in patients with idiopathic premature ovarian failure, particularly in the Korean population. Design : A prospective study. Materials and Methods : Eighty-three women affected by idiopathic premature ovarian failure were recruited for this study. Patient with known causes of premature ovarian failure were excluded : cytogenetic abnormalities, prior chemotherapy, prior bilateral oophorectomy. DNA was extracted from peripheral blood. Fragile X (FRAXA) premutation was evaluated by PCR amplification of and Southern blot analysis for FMR1 gene. Results : The FRAXA premutation was detected in three (3.6%) out of 83 patients with idiopathic premature ovarian failure. Conclusion : This result suggests that fragile X premutation screening is indicated in patients with idiopathic premature ovarian failure, particularly in the Korean population. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean | - |
dc.publisher | 대한산부인과내시경학회 | - |
dc.relation.isPartOf | Korean Journal of Gynecologic Endoscopy and Minimally Invasive Surgery (대한산부인과내시경학회잡지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 한국인 원인 불명 조기폐경 환자의 FMR1 유전자 양상 | - |
dc.title.alternative | Fragile X Premutation in Patients with Idiopathic Premature Ovarian Failure | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | 허창영 | - |
dc.contributor.googleauthor | 최영민 | - |
dc.contributor.googleauthor | 박성효 | - |
dc.contributor.googleauthor | 윤병구 | - |
dc.contributor.googleauthor | 이규섭 | - |
dc.contributor.googleauthor | 나용진 | - |
dc.contributor.googleauthor | 이병석 | - |
dc.contributor.googleauthor | 류철희 | - |
dc.contributor.googleauthor | 이화진 | - |
dc.contributor.googleauthor | 설혜원 | - |
dc.contributor.googleauthor | 오선경 | - |
dc.contributor.localId | A02795 | - |
dc.relation.journalcode | J02018 | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=2117732 | - |
dc.subject.keyword | Premature ovarian failure | - |
dc.subject.keyword | Fragile X syndrome | - |
dc.subject.keyword | Premutation | - |
dc.subject.keyword | Carrier | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | 이병석 | - |
dc.citation.volume | 46 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 978 | - |
dc.citation.endPage | 983 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gynecologic Endoscopy and Minimally Invasive Surgery (대한산부인과내시경학회잡지), Vol.46(5) : 978-983, 2003-05 | - |
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