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대한민국 성인에서 백혈구 수치와 폐 기능 검사 결과의 관련성: 2007-2009년 한국 국민건강영양조사

Other Titles
 Relationship between White Blood Cell Count and Pulmonary Function Test Results in Korean Adults: The 2007-2009 Korea National Health and Nutrition Examination Survey 
 이준혁  ;  유효선  ;  권유진  ;  이지원 
 Korean Journal of Family Practice (가정의학), Vol.8(1) : 52-58, 2018-02 
Journal Title
Korean Journal of Family Practice(가정의학)
Issue Date
Leukocytes ; Pulmonary Function Test ; Inflammation
Background: Systemic inflammation is associated with impaired pulmonary function. In this study, we investigated the relationship between white blood cell (WBC) count and pulmonary function test (PFT) result.
Methods: We analyzed data from the 2007–2009 Korea National Health and Nutrition Examination Survey. Finally, 8,464 patients with no history of asthma or chronic obstructive pulmonary disease (COPD), with WBC counts ranging from 3,000 to 10,000 cells/μL, and ability to interpret lung function test results were finally selected. The WBC counts were divided into four groups according to quartiles. The PFT results were divided into three groups as follows: normal, obstructive, and restrictive patterns. A weighted multinomial logistic regression analysis was performed to calculate the odds ratio for abnormal PFT patterns.
Results: The odds ratios were Q2 vs. Q1 1.196 (0.877–1.630), Q3 vs. Q1 1.338 (0.968–1.848), and Q4 vs. Q1 1.670 (1.224–2.280) for the obstructive pattern, and Q2 vs. Q1 0.987 (0.737–1.312), Q3 vs. Q1 1.066 (0.803–1.413), and Q4 vs. Q1 1.329 (1.001–1.766) for the restrictive pattern after being adjusted for age, sex, body mass index, waist circumference, smoking status, high-risk drinking, regular exercise, mean blood pressure, serum fasting blood glucose, total cholesterol, triglyceride, and diabetes mellitus, hypertension, and hyperlipidemia medication.
Conclusion: The highest WBC quartile was associated with an increased odds ratio for obstructive and restrictive patterns in subjects without asthma and COPD. The odds ratio of the obstructive pattern was higher than that of the restrictive pattern.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Lee, Jun-Hyuk(이준혁) ORCID logo https://orcid.org/0000-0002-1007-1633
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
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