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The relationship between lower urinary tract symptoms/benign prostatic hyperplasia and the number of components of metabolic syndrome

Authors
 Yeon Won Park  ;  Sung Bin Kim  ;  Hanna Kwon  ;  Hee Cheol Kang  ;  Kyunghee Cho  ;  Kung In Lee  ;  Yung Jung Kim  ;  Jun Ho Lee 
Citation
 UROLOGY, Vol.82(3) : 674-679, 2013-09 
Journal Title
 UROLOGY 
ISSN
 0090-4295 
Issue Date
2013-09
MeSH
Blood Glucose ; Blood Pressure ; Cholesterol, HDL / blood ; Humans ; Male ; Metabolic Syndrome / blood ; Metabolic Syndrome / complications* ; Middle Aged ; Organ Size ; Prostate / pathology* ; Prostate-Specific Antigen / blood ; Prostatic Hyperplasia / blood ; Prostatic Hyperplasia / complications* ; Prostatism / blood ; Prostatism / complications* ; Severity of Illness Index ; Triglycerides / blood ; Urine ; Urodynamics
Abstract
Objective: To investigate the relationship between lower urinary tract symptoms (LUTS)/benign prostate hyperplasia (BPH) and a number of components of metabolic syndrome (MetS). Methods: A total of 1224 male police officers aged 50-59 years who had participated in a health examination were included. LUTS/BPH were assessed by prostate-specific antigen, international prostate symptom score (IPSS), total prostate volume (TPV), maximum urinary flow rate (Qmax), and postvoid residual (PVR) urine volume. Testosterone levels were also examined. MetS was defined using National Cholesterol Education Program-Adult Treatment Panel III guidelines. The subjects were classified into 4 groups according to the number of exhibited MetS components (0, 1-2, 3, and 4-5). We used the Mantel-Haenszel extension test and logistic regression analyses. Results: MetS was diagnosed in 29.0% of the patients. The BPH ratio (IPSS >7, TPV ≥30 mL, and/or Qmax <15 mL/sec), TPV ≥30 mL, and PVR ≥50 mL significantly increased with an increasing number of metabolic abnormalities. The odds ratio (OR) in relation to a TPV ≥30 mL and a PVR ≥50 mL significantly rose as the number of positive MetS components increased after adjusting for age and testosterone. Additionally, the ORs (adjusting for age and testosterone) in relation to BPH also increased as the number of positive MetS components increased, with a suggestive threshold effect associated with 4-5 positive components (BPH: IPSS >7 + TPV ≥30 mL; 4 and 5 components, 3.496, 1.805-6.769, P = .001; BPH: IPSS >7 + TPV ≥30 mL + Qmax <15 mL/sec; 4 and 5 components, 5.458, 1.777-16.764, P = .002). Conclusion: According to our results, the cases of LUTS/BPH were positively associated with the number of MetS components.
Full Text
https://www.sciencedirect.com/science/article/pii/S0090429513004226
DOI
10.1016/j.urology.2013.03.047
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Cheol(강희철) ORCID logo https://orcid.org/0000-0002-0309-7448
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178522
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