Cited 7 times in
Evaluation of lymph node metastases: comparison of gadofluorine M-enhanced MRI and diffusion-weighted MRI in a rabbit VX2 rectal cancer model
DC Field | Value | Language |
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dc.contributor.author | 정용은 | - |
dc.date.accessioned | 2020-07-27T16:43:43Z | - |
dc.date.available | 2020-07-27T16:43:43Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178489 | - |
dc.description.abstract | Purpose: To compare the diagnostic performance of a diffusion-weighted imaging (DWI) dataset and a gadofluorine M-enhanced imaging dataset for identifying lymph node (LN) metastases in a rabbit rectal cancer model. Materials and methods: VX2 carcinomas were injected into the rectum of 26 rabbits. Four weeks later, T2-weighted imaging (T2WI), pre-T1WI, DWI, and post-T1WI were performed. Two radiologists independently reviewed the DWI set (T2WI, pre-T1WI, DWI) and the gadofluorine M set (T2WI, pre- and post-T1WI) and recorded their confidence scores for LN metastasis on a per-LN basis. Receiver operating characteristic (ROC) analysis was performed to compare the area under the ROC curve (A(z) ) of the two imaging sets. Histopathologic results were used as the reference standard. Results: The A(z) and sensitivity of the gadofluorine M set were comparable to those of the DWI set (A(z) , for reader 1, 0.849, 0.829, P = 0.571; for reader 2, 0.923, 0.876, P = 0.212; sensitivity, for reader 1, 97%, 97%; for reader 2, 97%, 92%, P = 0.304). The specificity of the former was greater than that of the latter (for reader 1, 65%, 53%, P = 0.0003; for reader 2, 81%, 68%, P = 0.01). Conclusion: Gadofluorine M-enhanced images provided greater specificity than DWI for identifying LN metastases, whereas the A(z) and sensitivity of the former were comparable to those of the latter. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Contrast Media* | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Image Enhancement / methods* | - |
dc.subject.MESH | Lymphatic Metastasis / diagnosis* | - |
dc.subject.MESH | Magnetic Resonance Imaging / methods* | - |
dc.subject.MESH | Neoplasm Transplantation | - |
dc.subject.MESH | Neoplasms, Experimental | - |
dc.subject.MESH | Organometallic Compounds* | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Rectal Neoplasms / pathology* | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.title | Evaluation of lymph node metastases: comparison of gadofluorine M-enhanced MRI and diffusion-weighted MRI in a rabbit VX2 rectal cancer model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Seung Ho Kim | - |
dc.contributor.googleauthor | Jeong Min Lee | - |
dc.contributor.googleauthor | Sung Kyoung Moon | - |
dc.contributor.googleauthor | Yong Eun Chung | - |
dc.contributor.googleauthor | Jin Ho Paik | - |
dc.contributor.googleauthor | Seung Hong Choi | - |
dc.contributor.googleauthor | Min Uk Kim | - |
dc.contributor.googleauthor | Joon Koo Han | - |
dc.contributor.googleauthor | Byung Ihn Choi | - |
dc.identifier.doi | 10.1002/jmri.23513 | - |
dc.contributor.localId | A03662 | - |
dc.relation.journalcode | J01567 | - |
dc.identifier.eissn | 1522-2586 | - |
dc.identifier.pmid | 22247081 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/jmri.23513 | - |
dc.contributor.alternativeName | Chung, Yong Eun | - |
dc.contributor.affiliatedAuthor | 정용은 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1179 | - |
dc.citation.endPage | 1186 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.35(5) : 1179-1186, 2012-05 | - |
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