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Prescribing Patterns of Antihypertensives for Treatment-Naïve Patients in South Korea: From Korean NHISS Claim Data

Authors
 Sang Hyuck Kim  ;  Dong Wook Shin  ;  Shinhye Kim  ;  Kyungdo Han  ;  Sang-Hyun Park  ;  Yul-Hee Kim  ;  Shin-Ae Jeon  ;  Yong-Chol Kwon 
Citation
 INTERNATIONAL JOURNAL OF HYPERTENSION, Vol.2019(4735876), 2019-08 
Journal Title
 INTERNATIONAL JOURNAL OF HYPERTENSION 
Issue Date
2019-08
Abstract
Background: Several factors influence the choice of antihypertensive drugs. To facilitate the rational use of drugs it is important to assess their prescription patterns over time. This study aims to evaluate doctors' prescribing patterns of antihypertensive drugs for drug-naïve patients in South Korea. Methods: The claims data of the Korean National Health Insurance Research Database from 1 January 2011 to 31 December 2015 were analyzed. The data virtually cover the entire South Korean population. Antihypertensive drugs were further subdivided into angiotensin receptor blockers (ARBs), angiotensin-converting enzyme inhibitors (ACEis), calcium channel blockers (CCBs), beta-blockers (BBs), and thiazide diuretics. The prescription pattern of antihypertensive drugs and associated factors were assessed according to the patients' characteristics, including associated comorbidities. Results: A total of 2,919,162 subjects had started taking antihypertension medications during the study period. ARB was the most frequently prescribed drug (51.6%) followed by CCB (45.0%), BB (18.5%), diuretics (17.0%), and ACEi (11.7%). Most patients were prescribed with monotherapy (66.7%) rather than combination therapy (33.3%), and CCB was the most frequently prescribed monotherapy drug (25.7%). For combination therapy, ARB + CCB was the most frequently prescribed combination, and the prescription frequency was found to be increasing. In patients prescribed with combination therapy, most had been prescribed single-pill fixed-dose combination. Conclusion: We identified the physicians' prescription patterns of antihypertensive drugs for treatment-naïve patients. The findings of this study can lead to a rational, evidence-based, and cost-effective improvement of prescription patterns in newly diagnosed hypertensive patients.
Files in This Item:
T201906499.pdf Download
DOI
10.1155/2019/4735876
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Shinhye(김신혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178126
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