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Compression-induced Expression of Glycolysis Genes in CAFs Correlates With EMT and Angiogenesis Gene Expression in Breast Cancer

 Baek Gil Kim  ;  Jin Sol Sung  ;  Yeonsue Jang  ;  Yoon Jin Cha  ;  Suki Kang  ;  Hyun Ho Han  ;  Joo Hyun Lee  ;  Nam Hoon Cho 
 COMMUNICATIONS BIOLOGY, Vol.2(313), 2019-08 
Journal Title
Issue Date
Breast cancer ; Cancer metabolism ; Cancer microenvironment
Tumor growth increases compressive stress within a tissue, which is associated with solid tumor progression. However, very little is known about how compressive stress contributes to tumor progression. Here, we show that compressive stress induces glycolysis in human breast cancer associated fibroblast (CAF) cells and thereby contributes to the expression of epithelial to mesenchymal (EMT)- and angiogenesis-related genes in breast cancer cells. Lactate production was increased in compressed CAF cells, in a manner dependent on the expression of metabolic genes ENO2, HK2, and PFKFB3. Conditioned medium from compressed CAFs promoted the proliferation of breast cancer cells and the expression of EMT and/or angiogenesis-related genes. In patient tissues with high compressive stress, the expression of compression-induced metabolic genes was significantly and positively correlated with EMT and/or angiogenesis-related gene expression and metastasis size. These findings illustrate a mechanotransduction pathway involving stromal glycolysis that may be relevant also for other solid tumours.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Suki(강숙희) ORCID logo https://orcid.org/0000-0002-9957-3479
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
Han, Hyun Ho(한현호) ORCID logo https://orcid.org/0000-0002-6268-0860
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