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Generation of an Induced Pluripotent Stem Cell (iPSC) Line From a 42-year-old Adult Cerebral Type X-linked Adrenoleukodystrophy (X-ALD) Patient

Authors
 Gyu-Bum Yeon  ;  Daryeon Son  ;  Phil Jun Kang  ;  Seung-Min Oh  ;  Hun Lim  ;  Hoon-Chul Kang  ;  Seungkwon You  ;  Dae-Sung Kim 
Citation
 STEM CELL RESEARCH, Vol.36 : e101425, 2019-04 
Journal Title
 STEM CELL RESEARCH 
ISSN
 1873-5061 
Issue Date
2019-04
MeSH
ATP Binding Cassette Transporter, Subfamily D, Member 1 / genetics* ; Adrenoleukodystrophy / genetics* ; Adult ; Cell Differentiation ; Cell Line* ; Cellular Reprogramming Techniques ; Humans ; INDEL Mutation ; Induced Pluripotent Stem Cells* ; Karyotype ; Male
Abstract
X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.
Files in This Item:
T201904653.pdf Download
DOI
10.1016/j.scr.2019.101425
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178101
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