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알코올 의존의 치료에서 Naltrexone의 사용

Other Titles
 Use of Naltrexone in the Treatment of Alcohol Dependence 
Authors
 남궁기  ;  조현상  ;  김병천  ;  현명호  ;  안혜리  ;  이희상  ;  유계준 
Citation
 Journal of Korean Academy fo Addiction Psychiatry (중독정신의학), Vol.1(1) : 14-26, 1997 
Journal Title
Journal of Korean Academy fo Addiction Psychiatry(중독정신의학)
ISSN
 1226-6035 
Issue Date
1997
Abstract
Two double-blind placebo controlled clinical trials have demonstrated that naltrexone, a pure opioid antagonist, appears
to be an effective adjunct to treatment of alcohol dependence.
Naltrexone alters endogenous opioids receptor activity, and
its alteration blocks a positive reinforcing effect of alcohol in
dopaminergic system. As a result, naltrexone reduces craving
for alcohol and alcoholic high. Clinically, naltrexone, which is
more compliant than disulfiram in alcoholics, results in fewer
drinking days, less drinking amount and lower rate of relapse
for alcoholic patients. Especially, those patients who initiatied
drinking, patients who received naltrexone and concurrent coping
skill/relapse prevention therapy are the least likely to relapse.
In addition, a recommendation for morning dosing and the
development of a pill taking routine are likely to increase the
patients compliance with naltrexone and ultimately the outcome of their treatment for alcoholic dependence.
In conclusion, the combined effects of naltrexone, psychosocial therapy and our patient support system need to be explored
so that an optimal approach to the treatment of alcoholism,
which is suitable for our own situation, should be developed.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178051
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