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심근의 허혈시 이데노신을 함유한 심정지액의 심근보호 효과

Other Titles
 The Protective Effect of Adenosine Included Cardioplegits in Myocardial Ischemia 
 유경종  ;  강면식  ;  이교준  ;  임상현  ;  김종훈  ;  조범구 
 Korean Journal of Thoracic and Cardiovascular Surgery (대한흉부외과학회지), Vol.30(9) : 847-853, 1997 
Journal Title
 Korean Journal of Thoracic and Cardiovascular Surgery (대한흉부외과학회지) 
Issue Date
Although the effects of adenosine on the heart, including the clinical suppression of cardiac arrhythmias, have been recognized for more than half a century, it is only in the last decade that the therapeutic potential of adenosine has been recognized. The objective of this study was to determine if augmentation of myocardial adenosine levels during global ischemia improves functional recovery after reperfusion. We used to modified Langendonf system to evaluate myocardial protective effect. Isolated rat hearts were subjected to 90 minutes of deep hypothermic arrest(15℃) with modified St. Thomas'Hospital cardioplegic solution used to provide myocardial protection. Myocardial adenosine levels were augmented during ischemia by providing exogenous adenosine in the cardioplegic solution. Two groups of hearts w re studied: (1) control group(n=10) cardioplegia alone; (2) adenosine group(n=10) adenosine(0.75mg/kg/min) added to the cardioplegic solution. Significantly better percent recovery(p<0.01) in hemodynamics(except heart rate) at 60 minutes after reperfusion was evident compared to baseline values in the adenosine group. (systolic no란ic pressure : 78.5±3.6% vs 66.6±5.9%, airtic overflow volume : 61.7± 11.6% vs 37.2± 15.4%, coronary flow volume 77.1±7.5% vs 57.2± 11.1%, and cardiac output : 65.6± 11.5% vs 44.2± 12.4%). Heart rate was similar in two groups(94.4±4.8% vs 95.3 ± 6.8%). Adenosine groups resulted in significantly rapid recovery time of heart beat after reperEusion(p<0.01) (24.5±7.6 sec. vs 179.0± 131.1sec.). In biochemical study, CPK levels(0.1 ±0.3U/L vs 1.4±0.8U/L) and lactic acid levels(0.08±0.Immol/L vs 0.34±0.2 mmol/L) were significantly low in adenosine groups(p<0.01). We concluded that adenosine included cardioplegia have better recovery effects after r perfusion in myocardial ischemia compared to adenosine free cardioplegia.
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1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Yoo, Kyung Jong(유경종) ORCID logo https://orcid.org/0000-0002-9858-140X
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