118 285

Cited 0 times in

심근의 허혈시 이데노신을 함유한 심정지액의 심근보호 효과

DC Field Value Language
dc.contributor.author유경종-
dc.date.accessioned2020-07-03T18:00:58Z-
dc.date.available2020-07-03T18:00:58Z-
dc.date.issued1997-
dc.identifier.issn0301-2859-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177960-
dc.description.abstractAlthough the effects of adenosine on the heart, including the clinical suppression of cardiac arrhythmias, have been recognized for more than half a century, it is only in the last decade that the therapeutic potential of adenosine has been recognized. The objective of this study was to determine if augmentation of myocardial adenosine levels during global ischemia improves functional recovery after reperfusion. We used to modified Langendonf system to evaluate myocardial protective effect. Isolated rat hearts were subjected to 90 minutes of deep hypothermic arrest(15℃) with modified St. Thomas'Hospital cardioplegic solution used to provide myocardial protection. Myocardial adenosine levels were augmented during ischemia by providing exogenous adenosine in the cardioplegic solution. Two groups of hearts w re studied: (1) control group(n=10) cardioplegia alone; (2) adenosine group(n=10) adenosine(0.75mg/kg/min) added to the cardioplegic solution. Significantly better percent recovery(p<0.01) in hemodynamics(except heart rate) at 60 minutes after reperfusion was evident compared to baseline values in the adenosine group. (systolic no란ic pressure : 78.5±3.6% vs 66.6±5.9%, airtic overflow volume : 61.7± 11.6% vs 37.2± 15.4%, coronary flow volume 77.1±7.5% vs 57.2± 11.1%, and cardiac output : 65.6± 11.5% vs 44.2± 12.4%). Heart rate was similar in two groups(94.4±4.8% vs 95.3 ± 6.8%). Adenosine groups resulted in significantly rapid recovery time of heart beat after reperEusion(p<0.01) (24.5±7.6 sec. vs 179.0± 131.1sec.). In biochemical study, CPK levels(0.1 ±0.3U/L vs 1.4±0.8U/L) and lactic acid levels(0.08±0.Immol/L vs 0.34±0.2 mmol/L) were significantly low in adenosine groups(p<0.01). We concluded that adenosine included cardioplegia have better recovery effects after r perfusion in myocardial ischemia compared to adenosine free cardioplegia.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한흉부외과학회-
dc.relation.isPartOfKorean Journal of Thoracic and Cardiovascular Surgery (대한흉부외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title심근의 허혈시 이데노신을 함유한 심정지액의 심근보호 효과-
dc.title.alternativeThe Protective Effect of Adenosine Included Cardioplegits in Myocardial Ischemia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.googleauthor유경종-
dc.contributor.googleauthor강면식-
dc.contributor.googleauthor이교준-
dc.contributor.googleauthor임상현-
dc.contributor.googleauthor김종훈-
dc.contributor.googleauthor조범구-
dc.contributor.localIdA02453-
dc.relation.journalcodeJ02127-
dc.identifier.eissn2093-6516-
dc.contributor.alternativeNameYoo, Kyung Jong-
dc.contributor.affiliatedAuthor유경종-
dc.citation.volume30-
dc.citation.number9-
dc.citation.startPage847-
dc.citation.endPage853-
dc.identifier.bibliographicCitationKorean Journal of Thoracic and Cardiovascular Surgery (대한흉부외과학회지), Vol.30(9) : 847-853, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.