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인체 진피 미세혈관 내피세포 표면에서 v - cadherin의 발현에 관한 연구

Other Titles
 Regulation of V - cadherin Expression on Human Dermal Microvascular Endothelial Cells 
 김이선  ;  최현주  ;  이민걸  ;  이광훈 
 Korean Journal of Dermatology (대한피부과학회지), Vol.35(5) : 924-930, 1997 
Journal Title
 Korean Journal of Dermatology (대한피부과학회지) 
Issue Date
Background: Cadherins are a supergene family of structurally related transmembrane glycoprotein. V-cadherin was a subclass of cadherin which expressed on endothelial cell as an endothelial cell cell adhesion molecule. The role of V-cadherin is still unclear in inflarnmation and immunologic responses. Objective : Our purpose was to demonstrate the expression and the regulation of V-cadherin expression on human dermal microvascular endothelial cells(HDMEC) by biological response modifier(BRM). Methods : The cell surface expression of V-cadherin on HDMEC that was unstimulated or pretreated with IL-1, TNF, IFN-, and PMA was evaluated by immunofluorescence flow cytometry and the enzyme-linked immunosorbent assay. Results : 1. V-cadherin was constitutively expressed on unstimulated HDMEC. 2. Maximal expression of V-cadherin was observed at 16 hrs after stimulation with IL-1, at 6 hrs after stimulation with TNF and at 24 hrs after stimulation with IFN- on HDMEC. 3. V-cadherin expression on HDMEC was increased after stimulation with IL-1 or PMA. Conclusion : V-cadherin was constitutively expressed on HDMEC, and V-cadherin expression can be regulated by BRM. These results suggest V-cadherin may contribute to inflammation. (Korean J Dermatol 1997;35(5): 924-930)
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hoon(이광훈)
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
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