Cited 0 times in
인체 진피 미세혈관 내피세포 표면에서 v - cadherin의 발현에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이민걸 | - |
dc.date.accessioned | 2020-07-03T17:57:55Z | - |
dc.date.available | 2020-07-03T17:57:55Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177934 | - |
dc.description.abstract | Background: Cadherins are a supergene family of structurally related transmembrane glycoprotein. V-cadherin was a subclass of cadherin which expressed on endothelial cell as an endothelial cell cell adhesion molecule. The role of V-cadherin is still unclear in inflarnmation and immunologic responses. Objective : Our purpose was to demonstrate the expression and the regulation of V-cadherin expression on human dermal microvascular endothelial cells(HDMEC) by biological response modifier(BRM). Methods : The cell surface expression of V-cadherin on HDMEC that was unstimulated or pretreated with IL-1, TNF, IFN-, and PMA was evaluated by immunofluorescence flow cytometry and the enzyme-linked immunosorbent assay. Results : 1. V-cadherin was constitutively expressed on unstimulated HDMEC. 2. Maximal expression of V-cadherin was observed at 16 hrs after stimulation with IL-1, at 6 hrs after stimulation with TNF and at 24 hrs after stimulation with IFN- on HDMEC. 3. V-cadherin expression on HDMEC was increased after stimulation with IL-1 or PMA. Conclusion : V-cadherin was constitutively expressed on HDMEC, and V-cadherin expression can be regulated by BRM. These results suggest V-cadherin may contribute to inflammation. (Korean J Dermatol 1997;35(5): 924-930) | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean | - |
dc.publisher | 대한피부과학회 | - |
dc.relation.isPartOf | Korean Journal of Dermatology (대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 인체 진피 미세혈관 내피세포 표면에서 v - cadherin의 발현에 관한 연구 | - |
dc.title.alternative | Regulation of V - cadherin Expression on Human Dermal Microvascular Endothelial Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | 김이선 | - |
dc.contributor.googleauthor | 최현주 | - |
dc.contributor.googleauthor | 이민걸 | - |
dc.contributor.googleauthor | 이광훈 | - |
dc.contributor.localId | A02674 | - |
dc.contributor.localId | A02779 | - |
dc.relation.journalcode | J02000 | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=1871874 | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.affiliatedAuthor | 이광훈 | - |
dc.contributor.affiliatedAuthor | 이민걸 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 924 | - |
dc.citation.endPage | 930 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology (대한피부과학회지), Vol.35(5) : 924-930, 1997 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.