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테트라싸이크린 함유 calcium sulfate의 서방형 국소 약물 송달 효과에 대한 연구

DC FieldValueLanguage
dc.contributor.author김종관-
dc.contributor.author박광균-
dc.contributor.author조규성-
dc.contributor.author채중규-
dc.contributor.author최성호-
dc.contributor.author박광균-
dc.contributor.author조규성-
dc.contributor.author채중규-
dc.contributor.author최성호-
dc.date.accessioned2020-07-03T17:53:27Z-
dc.date.available2020-07-03T17:53:27Z-
dc.date.issued1997-
dc.identifier.issn0250-3352-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177914-
dc.description.abstractPeriodontal disease is a bacterially caused by disease. To remove plaque and bacteria, it has been necessary to prescribe chemical drug to patient to subjugate therapeutic unvalue by mechanical scaling. As a patient on a high dosage of the antibiotics to maintain the effective concentration may produce unfavorable side effects, this decase demands the Slow-release local drug delivery system. The object of the experiment is to study on the slow-release local drug delivery effects of calcium sulfate compounded with tetracycline that mainly used in periodontal disease. Experimental groups were divided into four classes as follow: Group 1 : 10% tetracycline compounded modified calcium sulfate paste. Group 2 : compounded and hardened 10% tetracycline and calcium sulfate. Group 3 : compounded 10% tetracycline and calcium sulfate, used just before hardened. Group 4 : tetracycline-ethylene vinyl acetate fiber. In the four groups, release concentration, it's durability and the period of absorption by times are observed and concluded as follow: An effective concentration(4µm/ml) remained until 5 weeks in group 1, 9 days in group 2, 7 days in group 3, 15 days in group 4. It was fully fused at 11.8 days average in group 2 and 14.8 days average in group 3. There were no statistically significant results in tetracycline concentration until a week in group 2 and 3(p<0.05) These results suggest that tetracycline loaded calcium sulfate release sufficient tetracycline and fused in 11~14 days, so calcium sulfate is useful carrier as slow release local drug delivery system-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한치주과학회-
dc.relation.isPartOfJournal of Korean Academy of Periodontology (대한치주과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title테트라싸이크린 함유 calcium sulfate의 서방형 국소 약물 송달 효과에 대한 연구-
dc.title.alternativeSlow-release local drug delivery effect of tetracycline loaded calcium sulfate-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontics (치주과학교실)-
dc.contributor.googleauthor김성희-
dc.contributor.googleauthor최성호-
dc.contributor.googleauthor조규성-
dc.contributor.googleauthor채중규-
dc.contributor.googleauthor박광균-
dc.contributor.googleauthor김종관-
dc.contributor.localIdA00914-
dc.contributor.localIdA01429-
dc.contributor.localIdA01429-
dc.contributor.localIdA03810-
dc.contributor.localIdA03810-
dc.contributor.localIdA04024-
dc.contributor.localIdA04024-
dc.contributor.localIdA04081-
dc.contributor.localIdA04081-
dc.contributor.localIdA01429-
dc.contributor.localIdA01429-
dc.contributor.localIdA03810-
dc.contributor.localIdA03810-
dc.contributor.localIdA04024-
dc.contributor.localIdA04024-
dc.contributor.localIdA04081-
dc.contributor.localIdA04081-
dc.relation.journalcodeJ01492-
dc.contributor.alternativeNameKim, Chong Kwan-
dc.contributor.affiliatedAuthor김종관-
dc.contributor.affiliatedAuthor박광균-
dc.contributor.affiliatedAuthor박광균-
dc.contributor.affiliatedAuthor조규성-
dc.contributor.affiliatedAuthor조규성-
dc.contributor.affiliatedAuthor채중규-
dc.contributor.affiliatedAuthor채중규-
dc.contributor.affiliatedAuthor최성호-
dc.contributor.affiliatedAuthor최성호-
dc.contributor.affiliatedAuthor박광균-
dc.contributor.affiliatedAuthor박광균-
dc.contributor.affiliatedAuthor조규성-
dc.contributor.affiliatedAuthor조규성-
dc.contributor.affiliatedAuthor채중규-
dc.contributor.affiliatedAuthor채중규-
dc.contributor.affiliatedAuthor최성호-
dc.contributor.affiliatedAuthor최성호-
dc.citation.volume27-
dc.citation.number4-
dc.citation.startPage751-
dc.citation.endPage765-
dc.identifier.bibliographicCitationJournal of Korean Academy of Periodontology (대한치주과학회지), Vol.27(4) : 751-765, 1997-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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