치과 상아질 접착제의 돌연변이성 연구

Abstract

It is known that mutagenic effects can be related to various serious diseases, including cancer and birth defects. Therefore, detailed attention must be given to methodologies for evaluation of mutagenicty of dental materials, so that safe use of the products is ensured. The aims of this study were investigated the potential mutagenicity of compounds from 9 commercial dentin bonding agents (including primers and adhesives) sing the Ames Salmonella typhimurium/microsome assays. Through this tests, Tenure S Bond Enhancer was showed mutagenecity and Tenure and Prima less in Salmonella typhimurium TA100 without metabolic activation. Hipolite Dentine was showed slight and Veridonfil-Photo, Prima and Tokuso Mac-Bond less in Salmonella typhimurium TA100 with metabolic activation. No tested materials were showed mutagencity in Salmonella typhimurium TA1535 with or without metabolic activation. From this study, it was needed to further study with other kind of mutagenic tests.