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산전 태아 이상 선별 검사인 Triple Marker의 유용성

Other Titles
 Usefulness of Triple Marker Testing for Prenatal Diagnosis 
 최종락  ;  이경아  ;  송경순 
 Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.17(4) : 575-580, 1997 
Journal Title
 Korean Journal of Clinical Pathology (대한임상병리학회지) 
Issue Date
Background :Our purpose was to assess the utility of prenatal triple-marker (α- fetoprotein (AFP), β-human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) testing for chromosomal abnormalities in women with Down syndrome screen-positive results Method :Total 1,082 women between 15 and 21 weeks` gestation received second trimester Down syndrome risk evaluation by triple marker testing. AFP, β-hCG and uE3 were measured by Coat-A-Counts IRMA (Diagnostic Products Corporation, LA, USA), The risk for Down syndrome was calculated using a commercially available software program (AFP Expert; Benetech Medical System, Toronto, Canada) by use of a Down syndrome risk cutoff value(1:270 at midtrimester). Karyotypes were reviewed for 32 (54.2%) of these patients who received prenatal chromosome analysis Result :Fifty nine (5.5%) patients of the 1,082 women screened were identified as positive. Two chromosome abnormalities (47,XYY and 46,XX, int (9) ) were found in the 32 patients who underwent prenatal chromosome analysis (6.3%). Any cases on the abnormal serum tests torn out not to be associated with trisomy 21 Conclusion :Although triple marker screen appears to be an effective method detecting chromosome abnormalities there is a high false positive rate. Therefore, new screening test that reduce false positive rate is need to be introduced.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Kyung Soon(송경순)
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
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