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산전 태아 이상 선별 검사인 Triple Marker의 유용성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송경순 | - |
dc.contributor.author | 이경아 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2020-07-03T17:47:03Z | - |
dc.date.available | 2020-07-03T17:47:03Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 1015-6445 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177825 | - |
dc.description.abstract | Background :Our purpose was to assess the utility of prenatal triple-marker (α- fetoprotein (AFP), β-human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) testing for chromosomal abnormalities in women with Down syndrome screen-positive results Method :Total 1,082 women between 15 and 21 weeks` gestation received second trimester Down syndrome risk evaluation by triple marker testing. AFP, β-hCG and uE3 were measured by Coat-A-Counts IRMA (Diagnostic Products Corporation, LA, USA), The risk for Down syndrome was calculated using a commercially available software program (AFP Expert; Benetech Medical System, Toronto, Canada) by use of a Down syndrome risk cutoff value(1:270 at midtrimester). Karyotypes were reviewed for 32 (54.2%) of these patients who received prenatal chromosome analysis Result :Fifty nine (5.5%) patients of the 1,082 women screened were identified as positive. Two chromosome abnormalities (47,XYY and 46,XX, int (9) ) were found in the 32 patients who underwent prenatal chromosome analysis (6.3%). Any cases on the abnormal serum tests torn out not to be associated with trisomy 21 Conclusion :Although triple marker screen appears to be an effective method detecting chromosome abnormalities there is a high false positive rate. Therefore, new screening test that reduce false positive rate is need to be introduced. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한임상병리학회 | - |
dc.relation.isPartOf | Korean Journal of Clinical Pathology (대한임상병리학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 산전 태아 이상 선별 검사인 Triple Marker의 유용성 | - |
dc.title.alternative | Usefulness of Triple Marker Testing for Prenatal Diagnosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | 최종락 | - |
dc.contributor.googleauthor | 이경아 | - |
dc.contributor.googleauthor | 송경순 | - |
dc.contributor.localId | A02011 | - |
dc.contributor.localId | A02647 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J01988 | - |
dc.contributor.alternativeName | Song, Kyung Soon | - |
dc.contributor.affiliatedAuthor | 송경순 | - |
dc.contributor.affiliatedAuthor | 이경아 | - |
dc.contributor.affiliatedAuthor | 최종락 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 575 | - |
dc.citation.endPage | 580 | - |
dc.identifier.bibliographicCitation | Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.17(4) : 575-580, 1997 | - |
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