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산전 태아 이상 선별 검사인 Triple Marker의 유용성

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dc.contributor.author송경순-
dc.contributor.author이경아-
dc.contributor.author최종락-
dc.date.accessioned2020-07-03T17:47:03Z-
dc.date.available2020-07-03T17:47:03Z-
dc.date.issued1997-
dc.identifier.issn1015-6445-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177825-
dc.description.abstractBackground :Our purpose was to assess the utility of prenatal triple-marker (α- fetoprotein (AFP), β-human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) testing for chromosomal abnormalities in women with Down syndrome screen-positive results Method :Total 1,082 women between 15 and 21 weeks` gestation received second trimester Down syndrome risk evaluation by triple marker testing. AFP, β-hCG and uE3 were measured by Coat-A-Counts IRMA (Diagnostic Products Corporation, LA, USA), The risk for Down syndrome was calculated using a commercially available software program (AFP Expert; Benetech Medical System, Toronto, Canada) by use of a Down syndrome risk cutoff value(1:270 at midtrimester). Karyotypes were reviewed for 32 (54.2%) of these patients who received prenatal chromosome analysis Result :Fifty nine (5.5%) patients of the 1,082 women screened were identified as positive. Two chromosome abnormalities (47,XYY and 46,XX, int (9) ) were found in the 32 patients who underwent prenatal chromosome analysis (6.3%). Any cases on the abnormal serum tests torn out not to be associated with trisomy 21 Conclusion :Although triple marker screen appears to be an effective method detecting chromosome abnormalities there is a high false positive rate. Therefore, new screening test that reduce false positive rate is need to be introduced.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한임상병리학회-
dc.relation.isPartOfKorean Journal of Clinical Pathology (대한임상병리학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title산전 태아 이상 선별 검사인 Triple Marker의 유용성-
dc.title.alternativeUsefulness of Triple Marker Testing for Prenatal Diagnosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthor최종락-
dc.contributor.googleauthor이경아-
dc.contributor.googleauthor송경순-
dc.contributor.localIdA02011-
dc.contributor.localIdA02647-
dc.contributor.localIdA04182-
dc.relation.journalcodeJ01988-
dc.contributor.alternativeNameSong, Kyung Soon-
dc.contributor.affiliatedAuthor송경순-
dc.contributor.affiliatedAuthor이경아-
dc.contributor.affiliatedAuthor최종락-
dc.citation.volume17-
dc.citation.number4-
dc.citation.startPage575-
dc.citation.endPage580-
dc.identifier.bibliographicCitationKorean Journal of Clinical Pathology (대한임상병리학회지), Vol.17(4) : 575-580, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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