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Transforming Growth Factor-β1이 Trabecular Matrix Metalloproteinase 와 Inhibitor 의 분비 조절에 미치는 영향

Other Titles
 Regulation of the Levels of Trabecular Matrix Metalloproteinase and Inhibitor by Transforming Growth Factor-β1 
Authors
 성공제 
Citation
 Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.38(3) : 406-412, 1997 
Journal Title
 Journal of the Korean Ophthalmological Society (대한안과학회지) 
ISSN
 0378-6471 
Issue Date
1997
Abstract
The present study investigates the role of TGF-β1 as one of possible etiologic factors of glaucoma by studying the effect of TGF-β1 on the secretion of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase. The cultured samples of trabecular meshwork cells were treated with TGF-β1 in concentrations of 0, 100, 1000 and 10000 pg/ml. The samples were analysed for the secretion of MMP2 and timp2 through electrophoresis, western blot and TGF-β1 increased, the secretions of MMP2 and TIMP2 were not significantly changed after 24 hours. But the secretion of MMP2 was decreased while the secretion of TIMP2 was increased after 72 hours. The results suggest that TGF- β1 may be one of the etilogic factors of glaucoma(J Korean Ophthamol Soc 38:406~412, 1997).
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177748
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