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정상성상세포와 혈관내막세포를 공막 분리 동시배양으로 구축한 체외혈뇌장벽 모델

Other Titles
 In Vitro Blood-brain Barrier Model of Astrocyte and Endothelial Monolayer Co-culture Using Collagen-coated Microporous Membrane 
Authors
 윤수한  ;  조기홍  ;  김세혁  ;  안영환  ;  안영민  ;  조경기  ;  최중언 
Citation
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.26(5) : 617-624, 1997 
Journal Title
 Journal of Korean Neurosurgical Society (대한신경외과학회지) 
ISSN
 1225-8245 
Issue Date
1997
Keywords
Endothelial monolayer ; Coculture system ; Blood-brain barrier
Abstract
There are three types of the in vitro blood-brain barrier models that are endothelial monolayer, astrocyte and endothelial monolayer co-culture, and benign glioma and endothelial monolayer co-culture. We made these three types of models and evaluated permeability ratio for four molecular weight(MW 373, 4400, 9300, 38900) and electrical resistance of endothelial monolayer in each type. Astrocyte and endothelial monolayer co-culture showed the lowest permeability ratio and highest electrical resistance among them and that suggested astrocyte and endothelial monolayer co-culture was best for the in-vitro blood-brain barrier model.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Joong Uhn(최중언)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177736
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