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위암 환자에서 혈청 CA72-4의 진단적 의의

Other Titles
 The Diagnostic Significance of CA72-4 in Gastric Cancer Patient 
 이세준  ;  정재복  ;  신현승  ;  송시영  ;  강진경  ;  박인서 
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.29(1) : 9-16, 1997 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Background/Aims: The serum tumor markers, such as CEA and CA19-9, for gastric cancer have been used but their positive rates are not high. In this study the value of a new serum marker, CA72-4, was compared with the serum activities of CEA and CA19-9 in a consecutive series of patients with gastric cancer. Methods: Fifty-three patients(35 men and 18 women; mean age, 60 years) with histologically diagnosed adenocarcinoma of the stomach, were evaluated. Serum TAG-72 antigen was determined by a double determinant radioimmunometric assay kit, CA72-4, and serum CEA and CA19-9 levels were also measured. Results: CA72-4 had a very high specificity(100%) for benign gastric disease. In gastric carcinoma, the positive rate of CA72-4 was 28% and was not so different to that of CA19-9, 34%, and CEA, 32%. There was significantly increased positive rates of CA72-4, CA19-9 and CEA in patients with advanced gastric cancer than those with early gastric cancer(p<0.01) but no significant difference in CA72-4, CA19-9 and CEA. There was no significant difference in positive rates of CA72-4, CA19-9 and CEA in patients with distant metastases or lymph node metastases than those without metastases. The positive rates of combined use of serum CA72-4 and CA19-9, CA72-4 and CEA, and CA72-4, CA19-9 and CEA were 43%, 45% and 51%. Conclusions: The results of this study suggest that CA72-4 is not better in the serodiagnosis of gastric cancer than conventional tumor markers, CA19-9 and CEA. However, despite considerable numbers of advanced gastric cancer patients with positive CA72-4, there is little clinical significance of CA72-4 in the serodiagnosis of gastric cancer. (Korean J Gastroenterol 1997; 29:9 - 16)
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chung, Jae Bock(정재복)
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