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광범위한 간 침습을 보이는 간세포암에서의 간동맥내 Cis-Diamminedichloroplatinum 주업 요법에 의한 치료
DC Field | Value | Language |
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dc.contributor.author | 김명진 | - |
dc.date.accessioned | 2020-07-03T17:29:50Z | - |
dc.date.available | 2020-07-03T17:29:50Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0301-2867 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177596 | - |
dc.description.abstract | PURPOSE: To evaluate the therapeutic efficacy of intra-arterial infusion of Cis-Diamminedichloroplatinum (C-DDP) for the treatment of hepatocellular carcinomas with widespread involvement. MATERIALS AND METHODS: We retrospectively analyzed 22 patients who between July 1994 and June 1996 had undergone intra-arterial c-DDP infusion therapy for the treatment of hepatocellular carcinomas with widespread involvement. The hepatomas involved both lobes in ten, portal venous obstructions in fourteen, arterio-portal shunts in nine, and arterio-venous shunts in two. Proper hepatic artery was selected for infusion of 100mg/BSA of C-DDP. The same procedure was repeated every 3 to 4 weeks, and the total number of infusions was 65. On the basis of WHO criteria, response was classified as complete remission, partial remission, stable, or progression of the disease. Six-month and one-year survival rates were estimated, and adverse reactions were evaluated. RESULTS: Complete remission was noted in one patient (4.5%) and partial remission in three (13.6%), while 18 showed no response or progression after treatment. The six month survival rate was 59.1%, and the one-year survival rate was 32.1%. Adverse reactions included nausea/vomiting (59.8%), abdominal pain (9.2%), fever (8.0%), acute renal failure (2.3%) and hepatic encephalopathy (1.1%). These adverse reactions were, however, transient and reversible. CONCLUSION: Although the response rate is not high, intra-arterial C-DDP infusion therapy can be used as an alternative treatment for hepatocellular carcinomas with widespread involvement; adverse reactions are tolerable. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한방사선의학회 | - |
dc.relation.isPartOf | Journal of the Korean Radiologist Society (대한방사선의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 광범위한 간 침습을 보이는 간세포암에서의 간동맥내 Cis-Diamminedichloroplatinum 주업 요법에 의한 치료 | - |
dc.title.alternative | Intra-Arterial Cis-Diamminedichloroplatinum Infusion Treatment for Widespread Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | 박성일 | - |
dc.contributor.googleauthor | 양희철 | - |
dc.contributor.googleauthor | 이도연 | - |
dc.contributor.googleauthor | 심용운 | - |
dc.contributor.googleauthor | 김상흠 | - |
dc.contributor.googleauthor | 김명진 | - |
dc.contributor.googleauthor | 이종태 | - |
dc.contributor.googleauthor | 유형식 | - |
dc.contributor.localId | A00426 | - |
dc.relation.journalcode | J01844 | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | 김명진 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1025 | - |
dc.citation.endPage | 1031 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Radiologist Society (대한방사선의학회지), Vol.37(6) : 1025-1031, 1997 | - |
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