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폐출혈 및 뇌의 출혈성 종괴를 동반한 Wegener씨 육아종증 1 예

Other Titles
 A Case of Wegener`s Granulomatosis with Pulmonary Hemorrhage and a Hemorrhagic Mass in the Brain 
 박광주  ;  안철민  ;  이홍렬  ;  윤영원  ;  이승용  ;  김형중  ;  장준  ;  김성규  ;  이원영  ;  조상호 
 Korean Journal of Medicine (대한내과학회지), Vol.53(1) : 121-127, 1997 
Journal Title
 Korean Journal of Medicine (대한내과학회지) 
Issue Date
Wegener`s granulomatosis is a necrotizing, granulomatous vasculitis that involves multiple organs including the upper and lower respiratory tract and the kidney. The anitineutrophilic cytoplasmic antibody is a serologic marker with high sensitivity and specificity, which is useful in diagnosis of the disease and is considered to have a significant role in its pathogenesis. Wegener`s granulomatosis had been a fatal disease until combination therapy with cyclophosphamide and corticosteroids was introduced, which have improved the clinical course and the survival significantly. Wide spectrum of neurologic involvements such as peripheral and cranial neuritis, myelopathy, and cerebritis in Wegener`s granulomatosis has been reported, but manifestation of mass-like formation in the brain has rarely been reported. We experienced a case of Wegener`s granulomatosis with pulmonaty hemorrhage, renal failure, and a hemorrhagic mass in the brain. Its diagnosis was based on clinical findings, positive result of ANCA test, and the thoracoscopic lung biopsy. The hemorrhagic mass of the brain was found by magnetic resonance imaging and it is considered to be the result of granulomstous inflammation and vasculitis. With the combination therapy the cerebral lesion was slightly improved but the patient expired due to irreversible renal failure and progressive pulmonary hemorrhage.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Chul Min(안철민)
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