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Relationship between microsatellite instability and histologic types of colorectal carcinoma

Authors
 ZHEPIAO  ;  JONGSUN KIM  ;  NAM KYU KIM  ;  SUNG HOON NOH  ;  JAE Y. RO  ;  HOGUEN KIM 
Citation
 ONCOLOGY REPORTS, Vol.4(4) : 791-794, 1997 
Journal Title
 ONCOLOGY REPORTS 
ISSN
 1021-335X 
Issue Date
1997
Abstract
To evaluate the relationship between microsatellite instability (MIN) and histologic types of carcinomas in different organs, we analyzed how often MIN occurred in signet ring cell carcinomas of the colon (7 cases), stomach (13 cases), urinary bladder (5 cases), and prostate (3 cases). We also analyzed MIN and the expression of Epstein-Barr virus encoded RNA (EBER) transcripts in undifferentiated carcinoma with lymphoid stroma: 18 cases of lymphoepithelioma-like carcinoma (LELC) of the colorectum and 8 of the stomach and 9 cases of lymphoepithelial nasopharyngeal carcinoma (NPC). MIN was frequently observed in the signet ring cell carcinomas (4/7, 57%) and LELCs (12/18, 67%) of the colorectum, but was not found in the signer ring cell carcinomas of the urinary bladder or prostate or in NPCs and occurred significantly (p<0.05) less often in both gastric signer ring cell carcinoma (1/13, 8%) and gastric LELCs (1/8, 13%). Most of the gastric LELCs (5/6) and all of the NPCs in which MIN was not identified expressed EBER transcripts. Thus, MIN appear to be specific for signer ring cell carcinomas and LELCs of the colorectum, but there was no strong correlation between MIN and carcinomas in other organs. Different genetic alterations in the different organs could result in the formation of carcinomas of similar types.
Full Text
https://www.spandidos-publications.com/10.3892/or.4.4.791
DOI
10.3892/or.4.4.791
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Jong Sun(김종선) ORCID logo https://orcid.org/0000-0002-3149-669X
Kim, Hogeun(김호근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177391
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