0 18

Cited 0 times in

Relationship between p53 Overexpression and Gastric Cancer Progression

Authors
 Joo-Hang Kim  ;  Hyo Dong Uhm  ;  Soo Jung Gong  ;  Dong Hwan Shin  ;  Jin Hyuk Choi  ;  Hye Ran Lee  ;  Sung Hoon Noh  ;  Byung Soo Kim  ;  Jae Yong Cho  ;  Sun Young Rha  ;  Nae Choon Yoo  ;  Hyun Cheol Chung  ;  Jae Kyung Roh  ;  Jin Sik Min  ;  Kyong Sik Lee  ;  Byung Soo Kim 
Citation
 ONCOLOGY, Vol.54(2) : 166-170, 1997 
Journal Title
 ONCOLOGY 
ISSN
 0030-2414 
Issue Date
1997
MeSH
Adenocarcinoma/metabolism* ; Adenocarcinoma/pathology ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic* ; Humans ; Male ; Stomach Neoplasms/metabolism* ; Stomach Neoplasms/pathology ; Tumor Suppressor Protein p53/biosynthesis* ; Up-Regulation
Abstract
The relationship between p53 overexpression and clinicopathologic variables in gastric cancer was evaluated using 304 paraffin-embedded gastric tumor tissues. DO7, a murine monoclonal antiserum to p53 protein, was used for the immunohistochemical analysis. Positive staining was found in 129 tumors (42.2% of all tumors). Overexpression of p53 was not associated with sex, location of the tumor in the stomach or the type of Borrman's tumor. The overexpression rate of p53 protein was 30.4% (28/92) in stage II and 47.6% (101/212) in stage III (p = 0.007). While there was no significant association between p53 protein accumulation and T stage, there was a significant association with N stage, i.e. p53 overexpression was 27.4% (17/62) in the node-negative group and 46.3% (112/242) in the node-positive group (p = 0.011). In 79 patients, in whom corresponding primary gastric tumor and regional lymph node metastases were available, overexpression was found in 34 (43%) primary tumors and in 38 (48.1%) node samples, with a concordance rate of 67.1% in terms of p53 expression. Mean numbers of regional lymph node involvement by the tumor were 6.1 in the group with p53 overexpression and 5.2 in the group showing no immunoreactivity (p = 0.051). These findings suggest that p53 overexpression is related to gastric cancer progression and that immunoreactivity in the metastatic lymph nodes show the dependency on p53 expression in the primary tumor.
Full Text
https://www.karger.com/Article/Abstract/227682
DOI
10.1159/000227682
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Cho, Jae Yong(조재용) ORCID logo https://orcid.org/0000-0002-0926-1819
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177390
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links