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DNA strand scission and PC12 cell death inducedby salsolinol and copper

Authors
 Hyun-Jung Kim  ;  Hye-Ran Yoon  ;  Stacy Washington  ;  In I. Chang  ;  Young J. Oh  ;  Young-Joon Surh 
Citation
 NEUROSCIENCE LETTERS, Vol.238(3) : 95-98, 1997 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
1997
MeSH
Animals ; Cell Death/drug effects ; Copper/pharmacology* ; DNA Damage/drug effects* ; Isoquinolines/pharmacology* ; Oxidation-Reduction ; PC12 Cells/drug effects ; Rats ; Time Factors
Abstract
The naturally occurring neurotoxin, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol; SAL), has been speculated to contribute to Parkinson's disease and neuropathology of chronic alcoholism. In the present study, we found the capability of SAL to cause DNA cleavage in the presence of Cu(ll). Incubation of SAL and CuCl2 with calf thymus DNA caused strand breaks. Likewise, SAL in combination with Cu(ll) mediated the strand scission in øX174 RFI supercoiled DNA in a time-related manner. Neither Cu(ll) nor the catechol alone induced any appreciable DNA cleavage. The reaction of SAL with Cu(ll) was accompanied by the reduction of Cu(ll) to Cu(I). Furthermore, SAL induced cell death in cultured PC12 cells, which was exacerbated by Cu(ll). From these data, it seems likely that SAL undergoes redox cycling catalyzed by Cu(ll) to generate reactive species which may be responsible for the neurotoxic action of this catechol isoquinoline.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304394097008665?via%3Dihub
DOI
10.1016/s0304-3940(97)00866-5
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Chang, In Ik(장인익)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177388
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