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Involvement of α2-adrenoceptors in mediating sympathetic excitation of injured dorsal root ganglion neurons in rats with spinal nerve ligation

Authors
 Joong Woo Leem  ;  Young Seob Gwak  ;  Taick Sang Nam  ;  Kwang Se Paik 
Citation
 NEUROSCIENCE LETTERS, Vol.234(1) : 39-42, 1997 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
1997
MeSH
Adrenergic alpha-Agonists/pharmacology ; Adrenergic alpha-Antagonists/pharmacology ; Animals ; Clonidine/pharmacology ; Ganglia, Spinal/cytology ; Ganglia, Spinal/physiology* ; Ligation ; Male ; Neurons/physiology* ; Phenylephrine/pharmacology ; Prazosin/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic, alpha-2/physiology* ; Spinal Nerves/physiology* ; Yohimbine/pharmacology
Abstract
The present study examined the effects of sympathetic stimulation on the activity of primary afferent neurons that had peripheral axons being injured previously by a spinal nerve ligation. About 22% of afferents with injured fibers that showed spontaneous discharge were excited by sympathetic stimulation or systemic injection of adrenaline. Most sympathetically-excited afferent neurons had axons that conducted in the A-fiber range. This sympathetically-evoked afferent excitation was not affected by cutting the spinal nerve at a place close to the dorsal root ganglion (DRG). Yohimbine, alpha2-antagonist, suppressed sympathetically-evoked afferent excitation which was not affected by alpha1-antagonist prazosin. Clonidine, alpha2-agonist, exerted an excitatory effect, whereas alpha1-agonist phenylephrine had no effect on the activity of afferents with injured fibers. No afferent fibers in control preparations responded to sympathetic stimulation. The results suggest that after a spinal nerve ligation, injured DRG neurons with fast-conducting fibers become sensitive to sympathetic activity via activation of alpha2-adrenoceptors.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304394097006587?via%3Dihub
DOI
10.1016/s0304-3940(97)00658-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Nam, Taick Sang(남택상)
Leem, Joong Woo(임중우) ORCID logo https://orcid.org/0000-0002-1605-2230
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177387
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