Cited 31 times in
Involvement of α2-adrenoceptors in mediating sympathetic excitation of injured dorsal root ganglion neurons in rats with spinal nerve ligation
DC Field | Value | Language |
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dc.contributor.author | 남택상 | - |
dc.contributor.author | 임중우 | - |
dc.date.accessioned | 2020-07-03T17:15:36Z | - |
dc.date.available | 2020-07-03T17:15:36Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177387 | - |
dc.description.abstract | The present study examined the effects of sympathetic stimulation on the activity of primary afferent neurons that had peripheral axons being injured previously by a spinal nerve ligation. About 22% of afferents with injured fibers that showed spontaneous discharge were excited by sympathetic stimulation or systemic injection of adrenaline. Most sympathetically-excited afferent neurons had axons that conducted in the A-fiber range. This sympathetically-evoked afferent excitation was not affected by cutting the spinal nerve at a place close to the dorsal root ganglion (DRG). Yohimbine, alpha2-antagonist, suppressed sympathetically-evoked afferent excitation which was not affected by alpha1-antagonist prazosin. Clonidine, alpha2-agonist, exerted an excitatory effect, whereas alpha1-agonist phenylephrine had no effect on the activity of afferents with injured fibers. No afferent fibers in control preparations responded to sympathetic stimulation. The results suggest that after a spinal nerve ligation, injured DRG neurons with fast-conducting fibers become sensitive to sympathetic activity via activation of alpha2-adrenoceptors. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers Ireland | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adrenergic alpha-Agonists/pharmacology | - |
dc.subject.MESH | Adrenergic alpha-Antagonists/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Clonidine/pharmacology | - |
dc.subject.MESH | Ganglia, Spinal/cytology | - |
dc.subject.MESH | Ganglia, Spinal/physiology* | - |
dc.subject.MESH | Ligation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neurons/physiology* | - |
dc.subject.MESH | Phenylephrine/pharmacology | - |
dc.subject.MESH | Prazosin/pharmacology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, Adrenergic, alpha-2/physiology* | - |
dc.subject.MESH | Spinal Nerves/physiology* | - |
dc.subject.MESH | Yohimbine/pharmacology | - |
dc.title | Involvement of α2-adrenoceptors in mediating sympathetic excitation of injured dorsal root ganglion neurons in rats with spinal nerve ligation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | Joong Woo Leem | - |
dc.contributor.googleauthor | Young Seob Gwak | - |
dc.contributor.googleauthor | Taick Sang Nam | - |
dc.contributor.googleauthor | Kwang Se Paik | - |
dc.identifier.doi | 10.1016/s0304-3940(97)00658-7 | - |
dc.contributor.localId | A01271 | - |
dc.contributor.localId | A03409 | - |
dc.relation.journalcode | J02364 | - |
dc.identifier.eissn | 1872-7972 | - |
dc.identifier.pmid | 9347941 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0304394097006587?via%3Dihub | - |
dc.contributor.alternativeName | Nam, Taick Sang | - |
dc.contributor.affiliatedAuthor | 남택상 | - |
dc.contributor.affiliatedAuthor | 임중우 | - |
dc.citation.volume | 234 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 42 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, Vol.234(1) : 39-42, 1997 | - |
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