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Activity-dependent conduction velocity changes of A(delta) fibers in a rat model of neuropathy

Authors
 Won CK  ;  Oh SJ  ;  Jung SC  ;  Choi YR  ;  Kim YI  ;  Leem JW  ;  Shin HC 
Citation
 NEUROREPORT, Vol.8(15) : 3201-3205, 1997 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
1997
MeSH
Animals ; Ganglia, Spinal/pathology ; Ganglia, Spinal/physiopathology ; Models, Neurological ; Nerve Fibers, Myelinated/physiology* ; Neural Conduction/physiology* ; Peripheral Nerve Injuries ; Peripheral Nerves/physiopathology* ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve/injuries ; Sciatic Nerve/physiopathology
Abstract
Activity-dependent changes of conduction velocity (CV) and conduction block in single A(delta) fibers of primary afferent neurons were characterized in a rat model of neuropathy (NP). Injured dorsal root (DR) fiber in NP rats exhibited profoundly greater decreases of CV following impulse activity than did DR fiber in normal rats. Activity-dependent conduction block was absent up to 100 Hz of activity rate in DR fiber of NP rats, but was present above 25 Hz in normal rats. Profiles of activity dependence in sciatic fibers were similar in both NP and normal rats. These results suggest that nerve injury may alter activity-dependent hypoexcitability of A(delta) DR fibers. Furthermore, this excitability change may be responsible for the elevated pain perception in neuropathy.
Full Text
https://insights.ovid.com/crossref?an=00001756-199710200-00004
DOI
10.1097/00001756-199710200-00004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Leem, Joong Woo(임중우) ORCID logo https://orcid.org/0000-0002-1605-2230
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177386
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