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Mitochondrial Gene Transfer Ribonucleic Acid (tRNA)Leu(UUR) 3243 and tRNALys 8344 Mutations and Diabetes Mellitus in Korea

Authors
 HYUN CHUL LEE  ;  YOUNG DUK SONG  ;  HAI-RI LI  ;  JUM OK PARK  ;  HYUNG CHAN SUH  ;  EUNJIK LEE  ;  SEUNGKIL LIM  ;  KYUNGRAE KIM  ;  KAPBUM HUH 
Citation
 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.82(2) : 372-374, 1997 
Journal Title
 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 
ISSN
 0021-972X 
Issue Date
1997
MeSH
Adult ; DNA, Mitochondrial/genetics* ; Diabetes Mellitus/etiology ; Diabetes Mellitus/genetics* ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 2/genetics ; Diabetes, Gestational/genetics ; Female ; Genes* ; Humans ; Kidney Transplantation ; Korea ; Male ; Mutation* ; Postoperative Complications ; Pregnancy ; RNA, Transfer/genetics*
Abstract
The high prevalence of diabetic patients with a mutation in the mitochondrial gene (the 3243 and 8344 bp mutations) has been identified in Japan. To determine the prevalence of diabetic patients with those mutations in Korea, we randomly screened selected 503 clinical diabetic patients regardless of their diabetes types. We found only 1 patient with the mitochondrial DNA mutation at position 3243 (percent mutation, 32%), and the mitochondrial DNA mutation at position 8344 was not found in any of the patients. The affected subject was a 22-yr-old man with a history of myoclonic epilepsy and mild sensorineural hearing loss, a 1-yr duration of diabetes mellitus, and a low level C peptide response to oral glucose. Because of the low frequency of these mutations in the Korean diabetic population, we concluded that these particular mutations of mitochondrial DNA may not be a common contributor to diabetes mellitus in Korea.
DOI
10.1210/jcem.82.2.3747
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177317
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