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Mitochondrial Gene Transfer Ribonucleic Acid (tRNA)Leu(UUR) 3243 and tRNALys 8344 Mutations and Diabetes Mellitus in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.date.accessioned | 2020-07-03T17:09:47Z | - |
dc.date.available | 2020-07-03T17:09:47Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177317 | - |
dc.description.abstract | The high prevalence of diabetic patients with a mutation in the mitochondrial gene (the 3243 and 8344 bp mutations) has been identified in Japan. To determine the prevalence of diabetic patients with those mutations in Korea, we randomly screened selected 503 clinical diabetic patients regardless of their diabetes types. We found only 1 patient with the mitochondrial DNA mutation at position 3243 (percent mutation, 32%), and the mitochondrial DNA mutation at position 8344 was not found in any of the patients. The affected subject was a 22-yr-old man with a history of myoclonic epilepsy and mild sensorineural hearing loss, a 1-yr duration of diabetes mellitus, and a low level C peptide response to oral glucose. Because of the low frequency of these mutations in the Korean diabetic population, we concluded that these particular mutations of mitochondrial DNA may not be a common contributor to diabetes mellitus in Korea. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Endocrine Society | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | DNA, Mitochondrial/genetics* | - |
dc.subject.MESH | Diabetes Mellitus/etiology | - |
dc.subject.MESH | Diabetes Mellitus/genetics* | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/genetics | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/genetics | - |
dc.subject.MESH | Diabetes, Gestational/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genes* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Postoperative Complications | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | RNA, Transfer/genetics* | - |
dc.title | Mitochondrial Gene Transfer Ribonucleic Acid (tRNA)Leu(UUR) 3243 and tRNALys 8344 Mutations and Diabetes Mellitus in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | HYUN CHUL LEE | - |
dc.contributor.googleauthor | YOUNG DUK SONG | - |
dc.contributor.googleauthor | HAI-RI LI | - |
dc.contributor.googleauthor | JUM OK PARK | - |
dc.contributor.googleauthor | HYUNG CHAN SUH | - |
dc.contributor.googleauthor | EUNJIK LEE | - |
dc.contributor.googleauthor | SEUNGKIL LIM | - |
dc.contributor.googleauthor | KYUNGRAE KIM | - |
dc.contributor.googleauthor | KAPBUM HUH | - |
dc.identifier.doi | 10.1210/jcem.82.2.3747 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03375 | - |
dc.relation.journalcode | J01318 | - |
dc.identifier.eissn | 1945-7197 | - |
dc.identifier.pmid | 9024220 | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | 이현철 | - |
dc.contributor.affiliatedAuthor | 임승길 | - |
dc.citation.volume | 82 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 372 | - |
dc.citation.endPage | 374 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.82(2) : 372-374, 1997 | - |
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