0 23

Cited 0 times in

Epstein‐Barr virus in lymphoproliferative diseases in the sino‐nasal region: Close association with CD56+ immunophenotype and polymorphic‐reticulosis morphology

Authors
 Yasuhiko Tomita  ;  Masahiko Onsawa  ;  Ke Qiu  ;  Michiko Hashimoto  ;  Woo‐Ick Yang  ;  Gwi‐Eon Kim  ;  Katsuyuki Aozasa 
Citation
 INTERNATIONAL JOURNAL OF CANCER, Vol.70(1) : 9-13, 1997 
Journal Title
 INTERNATIONAL JOURNAL OF CANCER 
ISSN
 0020-7136 
Issue Date
1997
MeSH
Adolescent ; Adult ; Aged ; CD3 Complex/analysis ; Child ; Child, Preschool ; DNA, Viral/analysis ; Female ; Herpesvirus 4, Human/classification ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/isolation & purification* ; Humans ; Immunophenotyping ; Infant ; Lymphatic Diseases/immunology ; Lymphatic Diseases/virology* ; Lymphoma, B-Cell/classification ; Lymphoma, B-Cell/immunology ; Lymphoma, B-Cell/virology* ; Lymphoma, T-Cell/classification ; Lymphoma, T-Cell/immunology ; Lymphoma, T-Cell/virology* ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/virology ; Male ; Middle Aged ; Nose Neoplasms/immunology ; Nose Neoplasms/virology* ; Paranasal Sinus Neoplasms/immunology ; Paranasal Sinus Neoplasms/virology ; Polymerase Chain Reaction
Abstract
Association between Epstein-Barr virus (EBV) and nasal T-cell lymphoma (NTL) has been demonstrated. NTL has 2 types of histologic figures: one is ordinary non-Hodgkin's lymphoma (NHL) with monomorphous proliferation, and the other is polymorphic-reticulosis (PR) morphology. The presence of the EBV genome and its sub-types (A and B) were examined on paraffin-embedded specimens from 36 cases of sino-nasal lymphomas (SNL) collected from Seoul, Republic of Korea, where the frequency of NTL is high. Patients' ages ranged from 2 to 74 years (median 54 years) with a male-to-female ratio of 2.5:1. Immunophenotypically, 8 cases were B-cell type, 11 were T-cell type with CD56-, 14 were CD56+ type, and 3 were null-cell type. Five of 11 cases with ordinary NHL of T-cell type and 9 of 14 cases with PR were CD56+. The EBV genome was found by polymerase chain reaction (PCR) and in the tumor cells by in situ hybridization (ISH) in 1 of 4 B-cell type (25%), 5 of 10 T-cell type (50%), 11 of 13 CD56+ type (85%), and in both of null-cell type (100%). Of 16 cases with PR morphology, 15 (94%) were positive for the EBV genome. All of the 5 NTLs of ordinary NHL with CD56- were negative for EBV. Concerning the sub-type of EBV, 16 cases had type A, while none had type-B EBV. These findings suggest that NTL comprises 2 groups: EBV-positive NTLs are CD56+ and/or histologically PR, and EBV-negative NTLs are CD56- and histologically ordinary NHL. The current results on Korean patients, together with earlier studies on Japanese and Malaysian patients, have shown the predominance of type-A EBV in sino-nasal lymphoma in Asia.
DOI
10.1002/(sici)1097-0215(19970106)70:1<9::aid-ijc2>3.0.co;2-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177307
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links