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Epstein‐Barr virus in lymphoproliferative diseases in the sino‐nasal region: Close association with CD56+ immunophenotype and polymorphic‐reticulosis morphology

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dc.contributor.author양우익-
dc.date.accessioned2020-07-03T17:09:09Z-
dc.date.available2020-07-03T17:09:09Z-
dc.date.issued1997-
dc.identifier.issn0020-7136-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177307-
dc.description.abstractAssociation between Epstein-Barr virus (EBV) and nasal T-cell lymphoma (NTL) has been demonstrated. NTL has 2 types of histologic figures: one is ordinary non-Hodgkin's lymphoma (NHL) with monomorphous proliferation, and the other is polymorphic-reticulosis (PR) morphology. The presence of the EBV genome and its sub-types (A and B) were examined on paraffin-embedded specimens from 36 cases of sino-nasal lymphomas (SNL) collected from Seoul, Republic of Korea, where the frequency of NTL is high. Patients' ages ranged from 2 to 74 years (median 54 years) with a male-to-female ratio of 2.5:1. Immunophenotypically, 8 cases were B-cell type, 11 were T-cell type with CD56-, 14 were CD56+ type, and 3 were null-cell type. Five of 11 cases with ordinary NHL of T-cell type and 9 of 14 cases with PR were CD56+. The EBV genome was found by polymerase chain reaction (PCR) and in the tumor cells by in situ hybridization (ISH) in 1 of 4 B-cell type (25%), 5 of 10 T-cell type (50%), 11 of 13 CD56+ type (85%), and in both of null-cell type (100%). Of 16 cases with PR morphology, 15 (94%) were positive for the EBV genome. All of the 5 NTLs of ordinary NHL with CD56- were negative for EBV. Concerning the sub-type of EBV, 16 cases had type A, while none had type-B EBV. These findings suggest that NTL comprises 2 groups: EBV-positive NTLs are CD56+ and/or histologically PR, and EBV-negative NTLs are CD56- and histologically ordinary NHL. The current results on Korean patients, together with earlier studies on Japanese and Malaysian patients, have shown the predominance of type-A EBV in sino-nasal lymphoma in Asia.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCD3 Complex/analysis-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDNA, Viral/analysis-
dc.subject.MESHFemale-
dc.subject.MESHHerpesvirus 4, Human/classification-
dc.subject.MESHHerpesvirus 4, Human/genetics-
dc.subject.MESHHerpesvirus 4, Human/isolation & purification*-
dc.subject.MESHHumans-
dc.subject.MESHImmunophenotyping-
dc.subject.MESHInfant-
dc.subject.MESHLymphatic Diseases/immunology-
dc.subject.MESHLymphatic Diseases/virology*-
dc.subject.MESHLymphoma, B-Cell/classification-
dc.subject.MESHLymphoma, B-Cell/immunology-
dc.subject.MESHLymphoma, B-Cell/virology*-
dc.subject.MESHLymphoma, T-Cell/classification-
dc.subject.MESHLymphoma, T-Cell/immunology-
dc.subject.MESHLymphoma, T-Cell/virology*-
dc.subject.MESHLymphoproliferative Disorders/immunology-
dc.subject.MESHLymphoproliferative Disorders/virology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNose Neoplasms/immunology-
dc.subject.MESHNose Neoplasms/virology*-
dc.subject.MESHParanasal Sinus Neoplasms/immunology-
dc.subject.MESHParanasal Sinus Neoplasms/virology-
dc.subject.MESHPolymerase Chain Reaction-
dc.titleEpstein‐Barr virus in lymphoproliferative diseases in the sino‐nasal region: Close association with CD56+ immunophenotype and polymorphic‐reticulosis morphology-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorYasuhiko Tomita-
dc.contributor.googleauthorMasahiko Onsawa-
dc.contributor.googleauthorKe Qiu-
dc.contributor.googleauthorMichiko Hashimoto-
dc.contributor.googleauthorWoo‐Ick Yang-
dc.contributor.googleauthorGwi‐Eon Kim-
dc.contributor.googleauthorKatsuyuki Aozasa-
dc.identifier.doi10.1002/(sici)1097-0215(19970106)70:1<9::aid-ijc2>3.0.co;2-1-
dc.contributor.localIdA02300-
dc.relation.journalcodeJ01092-
dc.identifier.eissn1097-0215-
dc.identifier.pmid8985084-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.affiliatedAuthor양우익-
dc.citation.volume70-
dc.citation.number1-
dc.citation.startPage9-
dc.citation.endPage13-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CANCER, Vol.70(1) : 9-13, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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