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Epstein‐Barr virus in lymphoproliferative diseases in the sino‐nasal region: Close association with CD56+ immunophenotype and polymorphic‐reticulosis morphology
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양우익 | - |
dc.date.accessioned | 2020-07-03T17:09:09Z | - |
dc.date.available | 2020-07-03T17:09:09Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177307 | - |
dc.description.abstract | Association between Epstein-Barr virus (EBV) and nasal T-cell lymphoma (NTL) has been demonstrated. NTL has 2 types of histologic figures: one is ordinary non-Hodgkin's lymphoma (NHL) with monomorphous proliferation, and the other is polymorphic-reticulosis (PR) morphology. The presence of the EBV genome and its sub-types (A and B) were examined on paraffin-embedded specimens from 36 cases of sino-nasal lymphomas (SNL) collected from Seoul, Republic of Korea, where the frequency of NTL is high. Patients' ages ranged from 2 to 74 years (median 54 years) with a male-to-female ratio of 2.5:1. Immunophenotypically, 8 cases were B-cell type, 11 were T-cell type with CD56-, 14 were CD56+ type, and 3 were null-cell type. Five of 11 cases with ordinary NHL of T-cell type and 9 of 14 cases with PR were CD56+. The EBV genome was found by polymerase chain reaction (PCR) and in the tumor cells by in situ hybridization (ISH) in 1 of 4 B-cell type (25%), 5 of 10 T-cell type (50%), 11 of 13 CD56+ type (85%), and in both of null-cell type (100%). Of 16 cases with PR morphology, 15 (94%) were positive for the EBV genome. All of the 5 NTLs of ordinary NHL with CD56- were negative for EBV. Concerning the sub-type of EBV, 16 cases had type A, while none had type-B EBV. These findings suggest that NTL comprises 2 groups: EBV-positive NTLs are CD56+ and/or histologically PR, and EBV-negative NTLs are CD56- and histologically ordinary NHL. The current results on Korean patients, together with earlier studies on Japanese and Malaysian patients, have shown the predominance of type-A EBV in sino-nasal lymphoma in Asia. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | CD3 Complex/analysis | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | DNA, Viral/analysis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Herpesvirus 4, Human/classification | - |
dc.subject.MESH | Herpesvirus 4, Human/genetics | - |
dc.subject.MESH | Herpesvirus 4, Human/isolation & purification* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Lymphatic Diseases/immunology | - |
dc.subject.MESH | Lymphatic Diseases/virology* | - |
dc.subject.MESH | Lymphoma, B-Cell/classification | - |
dc.subject.MESH | Lymphoma, B-Cell/immunology | - |
dc.subject.MESH | Lymphoma, B-Cell/virology* | - |
dc.subject.MESH | Lymphoma, T-Cell/classification | - |
dc.subject.MESH | Lymphoma, T-Cell/immunology | - |
dc.subject.MESH | Lymphoma, T-Cell/virology* | - |
dc.subject.MESH | Lymphoproliferative Disorders/immunology | - |
dc.subject.MESH | Lymphoproliferative Disorders/virology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nose Neoplasms/immunology | - |
dc.subject.MESH | Nose Neoplasms/virology* | - |
dc.subject.MESH | Paranasal Sinus Neoplasms/immunology | - |
dc.subject.MESH | Paranasal Sinus Neoplasms/virology | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.title | Epstein‐Barr virus in lymphoproliferative diseases in the sino‐nasal region: Close association with CD56+ immunophenotype and polymorphic‐reticulosis morphology | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Yasuhiko Tomita | - |
dc.contributor.googleauthor | Masahiko Onsawa | - |
dc.contributor.googleauthor | Ke Qiu | - |
dc.contributor.googleauthor | Michiko Hashimoto | - |
dc.contributor.googleauthor | Woo‐Ick Yang | - |
dc.contributor.googleauthor | Gwi‐Eon Kim | - |
dc.contributor.googleauthor | Katsuyuki Aozasa | - |
dc.identifier.doi | 10.1002/(sici)1097-0215(19970106)70:1<9::aid-ijc2>3.0.co;2-1 | - |
dc.contributor.localId | A02300 | - |
dc.relation.journalcode | J01092 | - |
dc.identifier.eissn | 1097-0215 | - |
dc.identifier.pmid | 8985084 | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | 양우익 | - |
dc.citation.volume | 70 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9 | - |
dc.citation.endPage | 13 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, Vol.70(1) : 9-13, 1997 | - |
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