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Apolipoprotein E genotyping and phenotyping in type II diabetes mellitus patients with hypertriglyceridemia

Authors
 Jeong Ho Kim  ;  Eun Jig Lee  ;  Oh Hun Kwon 
Citation
 CLINICAL BIOCHEMISTRY, Vol.30(1) : 47-52, 1997 
Journal Title
 CLINICAL BIOCHEMISTRY 
ISSN
 0009-9120 
Issue Date
1997
MeSH
Aged ; Alleles ; Apolipoproteins E/blood ; Apolipoproteins E/genetics* ; Cholesterol/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/genetics* ; Genotype ; Humans ; Hypertriglyceridemia/blood ; Hypertriglyceridemia/genetics* ; Middle Aged ; Phenotype ; Polymorphism, Genetic/genetics ; Polymorphism, Genetic/physiology
Abstract
OBJECTIVES: We investigated the possible effect of apolipoprotein E (apo E) polymorphism on hypertriglyceridemia in type II diabetes mellitus (DM) patients by both apo E genotyping and phenotyping methods. DESIGN AND METHODS: Eighty Korean type II DM patients were evaluated. Restriction isotyping after DNA amplification was used for apo E genotyping. The isoelectric focusing of neuraminidase-treated sera followed by immunoblotting was used for apo E phenotyping. RESULTS: The concordant rate between apo E genotyping and phenotyping was 96.3%. Apo E genotype frequencies for all 77 concordant cases were as follows: 72.7% for epsilon 3/3; 16.9% for epsilon 3/4; 7.8% for epsilon 2/3; 1.3% for epsilon 2/4, 1.3% for epsilon 4/4; and 0% for epsilon 2/2. There were no significant differences in apo E genotype frequencies between hypertriglyceridemic (n = 42) and normotriglyceridemic (n = 35) groups. CONCLUSIONS: Our findings could not support the association between apo E polymorphism and hypertriglyceridemia among type II DM patients.
Full Text
https://www.sciencedirect.com/science/article/pii/S0009912096001300?via%3Dihub
DOI
10.1016/s0009-9120(96)00130-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177288
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