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Apolipoprotein E genotyping and phenotyping in type II diabetes mellitus patients with hypertriglyceridemia
DC Field | Value | Language |
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dc.contributor.author | 김정호 | - |
dc.date.accessioned | 2020-07-03T17:07:49Z | - |
dc.date.available | 2020-07-03T17:07:49Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177288 | - |
dc.description.abstract | OBJECTIVES: We investigated the possible effect of apolipoprotein E (apo E) polymorphism on hypertriglyceridemia in type II diabetes mellitus (DM) patients by both apo E genotyping and phenotyping methods. DESIGN AND METHODS: Eighty Korean type II DM patients were evaluated. Restriction isotyping after DNA amplification was used for apo E genotyping. The isoelectric focusing of neuraminidase-treated sera followed by immunoblotting was used for apo E phenotyping. RESULTS: The concordant rate between apo E genotyping and phenotyping was 96.3%. Apo E genotype frequencies for all 77 concordant cases were as follows: 72.7% for epsilon 3/3; 16.9% for epsilon 3/4; 7.8% for epsilon 2/3; 1.3% for epsilon 2/4, 1.3% for epsilon 4/4; and 0% for epsilon 2/2. There were no significant differences in apo E genotype frequencies between hypertriglyceridemic (n = 42) and normotriglyceridemic (n = 35) groups. CONCLUSIONS: Our findings could not support the association between apo E polymorphism and hypertriglyceridemia among type II DM patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Apolipoproteins E/blood | - |
dc.subject.MESH | Apolipoproteins E/genetics* | - |
dc.subject.MESH | Cholesterol/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/genetics* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertriglyceridemia/blood | - |
dc.subject.MESH | Hypertriglyceridemia/genetics* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Polymorphism, Genetic/genetics | - |
dc.subject.MESH | Polymorphism, Genetic/physiology | - |
dc.title | Apolipoprotein E genotyping and phenotyping in type II diabetes mellitus patients with hypertriglyceridemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Jeong Ho Kim | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Oh Hun Kwon | - |
dc.identifier.doi | 10.1016/s0009-9120(96)00130-0 | - |
dc.contributor.localId | A00903 | - |
dc.relation.journalcode | J00561 | - |
dc.identifier.eissn | 1873-2933 | - |
dc.identifier.pmid | 9056109 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0009912096001300?via%3Dihub | - |
dc.contributor.alternativeName | Kim, Jeong Ho | - |
dc.contributor.affiliatedAuthor | 김정호 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 47 | - |
dc.citation.endPage | 52 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, Vol.30(1) : 47-52, 1997 | - |
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