0 13

Cited 0 times in

Effects of capsaicin on chemically-induced two-stage mouse skin carcinogenesis

Authors
 Kwang-Kyun Park  ;  Young-Joon Surh 
Citation
 CANCER LETTERS, Vol.114(1-2) : 183-184, 1997 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
1997
MeSH
9,10-Dimethyl-1,2-benzanthracene ; Administration, Topical ; Animals ; Capsaicin/administration & dosage ; Capsaicin/toxicity* ; Carcinogens ; Cocarcinogenesis ; Female ; Mice ; Mice, Inbred ICR ; Skin Neoplasms/chemically induced* ; Tetradecanoylphorbol Acetate
Abstract
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a principal pungent ingredient of hot red peppers. There are some controversies with regard to its inherent tumorigenicity and mutagenicity. The present work was undertaken to assess tumor initiating and promotional effects of capsaicin in a two-stage mouse skin carcinogenesis model. A single topical application of capsaicin (10 micromol) followed by twice-weekly applications of 12-O-tetradecanoylphorbol-13-acetate onto shaven backs of female ICR mice resulted in no significant increases in incidence and multiplicity of skin tumors, compared with the solvent-pretreated control animals. Repeated topical applications of capsaicin alone failed to promote 7,12-dimethylbenz[a]anthracene-initiated mouse skin tumorigenesis, but moderately inhibited the papilloma formation when given prior to each topical dose of phorbol ester.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304383597046570?via%3Dihub
DOI
10.1016/s0304-3835(97)04657-0
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177280
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links