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Regulation of the seven human alcohol dehydrogenase genes

Authors
 Howard J. Edenberg  ;  Celeste J. Brown  ;  Man-Wook Hur  ;  Shailaja Kotagiri  ;  Mei Li  ;  Lu Zhang  ;  Xin Zhi 
Citation
 ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, Vol.414 : 339-345, 1997 
Journal Title
 ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 
ISSN
 0065-2598 
Issue Date
1997
MeSH
Alcohol Dehydrogenase/biosynthesis* ; Alcohol Dehydrogenase/genetics* ; Aldehyde Oxidoreductases/biosynthesis ; Aldehyde Oxidoreductases/genetics ; Animals ; Biological Evolution ; Gene Expression Regulation, Enzymologic* ; Genetic Variation ; Humans ; Isoenzymes/biosynthesis* ; Isoenzymes/genetics* ; Mice ; Multigene Family* ; Organ Specificity ; Promoter Regions, Genetic ; TATA Box
Abstract
The human alcohol dehydrogenase gene family consists of seven genes with distinct but overlapping patterns of expression. ADH enzymes metabolize a wide range of alcohols. Some of the ADH enzymes catalyze the first, rate-limiting step in the oxidative metabolism of ethanol. This pathway generates acetaldehyde as an intermediate, which in turn is oxidized by aldehyde dehydrogenase to acetate. Allelic differences in ADH2 and ADH3 genes encode forms of the enzymes that differ in their kinetic properties toward ethanol. These differences have been shown to affect the risk for alcoholism in Japanese and Chinese individuals (Thomasson et al. 1991; Thomasson et al. 1994; Thomasson et al. 1993; Crabb et al. 1995; Tanaka et al. 1996; Yamauchi et al. 1995; Maezawa et al. 1995; Tu and Israel, 1995). We hypothesize that differences in the expression of these genes could also affect the metabolism of ethanol, and thereby modify the risk for alcoholism in other populations.
Full Text
https://link.springer.com/content/pdf/10.1007%2F978-1-4615-5871-2.pdf
DOI
10.1007/978-1-4615-5871-2_39
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Hur, Man Wook(허만욱) ORCID logo https://orcid.org/0000-0002-3416-1334
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177246
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