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산전스테로이드 투여가 수액제한 요법을 시행받은 극저출생체중아의 수액 균형 및 예후에 미치는 영향

Other Titles
 Effects of Antenatal Steroid on Fluid Balance and Clinical Outcome in Very Low Birth Weight Infants Receiving Restricted Fluid Regimen 
 김정년  ;  이철  ;  박민수  ;  남궁란  ;  박국인  ;  한동관 
 Korean Journal of Perinatology (대한주산의학회잡지), Vol.9(2) : 145-151, 1998 
Journal Title
 Korean Journal of Perinatology (대한주산의학회잡지) 
Issue Date
Purpose : Antenatal steroid(ANS) therapy in premature infants is an effective therapeutic strategy in reducing the incidence of respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, and patent ductus arteriosus. For premature infants to gain improved survival, adequate weight loss during early postnatal days and maintenance of electrolyte balance is important, however, it is uncertain that ANS affect them. We hypothesized that ANS augment fluid and electrolyte balance and clinical outcome of very low birth weight(VLBW) who had received restricted fluid regimen. Methods : Mechanically ventilated VLBW intents who survived over 30 days were selected. We reviewed medical records to compare weight loss, urine output, electrolyte concentration, blood pressure during five days of life and clinical outcome between premature infects who received ANS(n= 15) and who were not(n=58). Results : Gestational age, birth weight were similar between two groups. Volume of administered fluid, urine output, and initial weight loss during first five days of life were similar, however, weight loss on postnatal day five were lower in study group than control group(p=.039). Blood pressure, serum sodium concentration, serum potassium concentration, and urine specific gravity were similar between two groups. Incidence of respiratory distress syndrome was lower in study group(20%) than control group(48%)(p=.041), however, incidence of sepsis were greater in study group(33%) than control group(7%)(p=.029). Conclusion : ANS did not affect fluid and electrolyte balance of very low birth weight(VLBW) intents who had received restricted fluid regimen. ANS decreased the incidence of respiratory distress syndrome in this population, however, increased the incidence of sepsis.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Lee, Chul(이철)
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