0 31

Cited 0 times in

Sequence Analysis of the 5′-Flanking Region of the Gene Encoding Human HOXA-7

Authors
 Myoung Hee Kim  ;  Myungsun Cho  ;  Dalkeun Park 
Citation
 SOMATIC CELL AND MOLECULAR GENETICS, Vol.24(6) : 371-374, 1998 
Journal Title
 SOMATIC CELL AND MOLECULAR GENETICS 
ISSN
 0740-7750 
Issue Date
1998
MeSH
5' Untranslated Regions/chemistry* ; 5' Untranslated Regions/genetics* ; Amino Acid Sequence ; Animals ; Base Sequence ; Homeodomain Proteins/chemistry ; Homeodomain Proteins/genetics* ; Humans ; Mice ; Molecular Sequence Data ; Neoplasm Proteins* ; Sequence Analysis, DNA/methods
Abstract
We have isolated and characterized the immediate 5′-flanking region (886 bp) of the gene encoding human HOXA-7. When the total sequence was compared with those of mice, 93% of the 3′ 518 bp (nt 370–886) sequences were identical, in which the 245 bases just preceding theAUG initiator codon (nt 614) was as highly conserved as in the coding region (nt 614–886). Sequences further upstream (nt 1–370) by comparison were highly diverged. In the 245 bp region, 8 stop and 3 initiation (including the initiator) codons were located, and a 50-aa long presumptive polypeptide was encoded. Nucleotide sequence analysis revealed three Spl and oneAP2 binding sites, as well as one CAATbox. However, there was no consensus sequence for a TATA box in the 5′ flanking region. One RARE repeat, one krox20 and three Hox-PBC binding sites were detected. Since many of the factor recognition sites were located in the immediate 5′ flanking sequences of a highly-conserved region, it might be speculated that a regulatory mechanism for Hox gene expression is conserved throughout the evolution and one possible mechanism could be at the post-translational level.
Full Text
http://link.springer.com/article/10.1023/A:1024446625716
DOI
10.1023/A:1024446625716
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177200
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links