비전형적 항정신병약물의 약리학

Abstract

As clozapine is known to treat both the positive and negative symptoms of schizophrenia while causing a minimum of extrapyramidal adverse effects, and the characteristics of dozapine appear to be related with the antagonism not only dopamine but also serotonin receptors. Several serotonm-dopamine antagonists was developed. These drugs may be classified according to their pharmacodynamic site of action, s.g., serotonin, dopamine, a, antagonists such as risperidone, sertindole, ziprasidone ; multiple receptors antagonists including clozapine, olanzapine, quetiapine. The authors attempt to overview the common and different aspects of pharmacokinetics and phatuiacodynamics of various serotonin-dopamine antagonists.