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임신중독증 산모 혈청의 인슐린 유사 성장인자 결합 단백질-1

Other Titles
 Insulin-like Growth Factor Binding Protein-1 ( IGF-BP-1 ) in Maternal Serum of Women with Pregnancy Induced Hypertension 
 유용균  ;  조재성  ;  최형민  ;  이연혜  ;  박용원 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.41(5) : 1268-1272, 1998 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회잡지)
Issue Date
IGF-BP-1 is known to have a important role in fetal growth and development by modulation of the actions of IGF, but also has its independent actions and in vitro IGF- BP-1 inhibits cytotrophoblastic invasion into decidualized stromal multilayers. The goals of this study are to investigate the IGF-BP-1 in maternal serum of women with pregnancy induced hypertension and without and evaluate the relationship between IGF-BP-1 of maternal serum and intrauterine growth restriction. IGF-BP-1 levels in maternal serum with pregnacy induced hypertension were 183.5±46.3 ng/ml compared with 148.9±44.3 ng/ml in controls (p<0.01). IGF-BP-1 levels in maternal serum with pregnancy induced hypertension and intrauterine growth restriction were 199.1±44.8 ng/ml compared with 167.1±42.2 ng/ml in maternal serum with pregnancy induced hypertension but without intrauterine growth restriction. In conclusion, elevated maternal serum IGF-BP-1 levels may contribute to restricted placental and therefore fetal growth.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Won(박용원)
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