임신중독증 산모 혈청의 인슐린 유사 성장인자 결합 단백질-1

Abstract

IGF-BP-1 is known to have a important role in fetal growth and development by modulation of the actions of IGF, but also has its independent actions and in vitro IGF- BP-1 inhibits cytotrophoblastic invasion into decidualized stromal multilayers. The goals of this study are to investigate the IGF-BP-1 in maternal serum of women with pregnancy induced hypertension and without and evaluate the relationship between IGF-BP-1 of maternal serum and intrauterine growth restriction. IGF-BP-1 levels in maternal serum with pregnacy induced hypertension were 183.5±46.3 ng/ml compared with 148.9±44.3 ng/ml in controls (p＜0.01). IGF-BP-1 levels in maternal serum with pregnancy induced hypertension and intrauterine growth restriction were 199.1±44.8 ng/ml compared with 167.1±42.2 ng/ml in maternal serum with pregnancy induced hypertension but without intrauterine growth restriction. In conclusion, elevated maternal serum IGF-BP-1 levels may contribute to restricted placental and therefore fetal growth.