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Deletion mapping of chromosome 4q in hepatocellular carcinoma

Authors
 Zhe Piao  ;  Chanil Park  ;  Jeon-Han Park  ;  Hoguen Kim 
Citation
 INTERNATIONAL JOURNAL OF CANCER, Vol.79(4) : 356-360, 1998 
Journal Title
INTERNATIONAL JOURNAL OF CANCER
ISSN
 0020-7136 
Issue Date
1998
MeSH
Autoradiography ; Carcinoma, Hepatocellular/genetics* ; Chromosome Deletion* ; Chromosome Mapping ; Chromosomes, Human, Pair 4* ; Humans ; Liver Neoplasms/genetics* ; Microsatellite Repeats
Abstract
Hepatocellular carcinoma (HCC) frequently shows a loss of heterozygosity (LOH) on chromosome 4q. In order to define the commonly affected region on chromosome 4q for further positional cloning of the putative tumor suppressor gene, we carried out allelic imbalance (AI) studies in 41 HCCs using a panel of 43 microsatellite markers. Thirty-four cases (82.9%) showed AI at one or more loci. Detailed deletion mapping identified 7 independent, frequently deleted regions on this chromosome arm. These were the (1) D4S1615 locus, (2) D4S1598 locus, (3) D4S620 locus, (4) D4S1566 and D4S2979 loci, (5) D4S1617 and D4S1545 loci, (6)D4S1537 locus; and (7) from the D4S2920 to D4S2954 locus. Among these 7 frequently deleted regions, 5 were associated with tumor differentiation. Our results suggest that several putative tumor suppressor genes may be present on chromosome 4q and that the AI of chromosome 4q may play a role in the aggressive progression of HCC.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0215(19980821)79:4%3C356::AID-IJC8%3E3.0.CO;2-U/abstract
DOI
10.1002/(SICI)1097-0215(19980821)79:4<356::AID-IJC8>3.0.CO;2-U
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
Park, Chan Il(박찬일)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177040
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