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Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus

Authors
 Yong Park  ;  Sang Kwon Lee  ;  Dea Sik Kim  ;  Jang Ho Lee  ;  Chang H. Lee  ;  Chan Ho Song 
Citation
 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.16(3) : 283-288, 1998 
Journal Title
 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 
ISSN
 0392-856X 
Issue Date
1998
MeSH
Adolescent ; Adult ; Antibodies, Antinuclear/blood ; Antigen-Antibody Complex/blood ; Complement C3/analysis ; Complement C4/analysis ; Disease Progression ; Female ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Interleukin-10/blood* ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/immunology* ; Male ; Middle Aged
Abstract
OBJECTIVE: To determine serum interleukin-10 (IL-10) levels in systemic lupus erythematosus (SLE) patients and to assess their relationship with disease activity. METHODS: Forty-one SLE patients and 35 controls were studied. Paired serum samples were collected from all SLE patients at the time of their presentation with active disease and at 4 weeks after the institution of treatment. IL-10 levels were determined in the sera and were compared with disease activity, measured using the SLE Disease Activity Index (SLEDAI) and laboratory parameters such as the circulating immune complexes (CIC), C3, C4, anti-DNA antibody, IgG, IgM, and IgA. RESULTS: The IL-10 levels in SLE patients were significantly higher than those of controls (mean +/- SE, 29.2 +/- 6.8 vs. 3.5 +/- 0.6 pg/ml, p < 0.01). Elevated IL-10 levels correlated well with the SLEDAI in SLE patients (r = 0.46, p < 0.01), but did not correlate with other laboratory activity indices. The changes in serum IL-10 levels also correlated with the changes in the SLEDAI score during the patients' disease course (r = 0.51, p < 0.01). CONCLUSION: Serum levels of IL-10 are elevated in SLE patients and increased IL-10 correlates well with SLE disease activity.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Park, Yong Beom(박용범)
Song, Chang Ho(송창호)
Lee, Soo Kon(이수곤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177036
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