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Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus
DC Field | Value | Language |
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dc.contributor.author | 김동수 | - |
dc.contributor.author | 박용범 | - |
dc.contributor.author | 송창호 | - |
dc.contributor.author | 이수곤 | - |
dc.date.accessioned | 2020-07-02T17:46:39Z | - |
dc.date.available | 2020-07-02T17:46:39Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177036 | - |
dc.description.abstract | OBJECTIVE: To determine serum interleukin-10 (IL-10) levels in systemic lupus erythematosus (SLE) patients and to assess their relationship with disease activity. METHODS: Forty-one SLE patients and 35 controls were studied. Paired serum samples were collected from all SLE patients at the time of their presentation with active disease and at 4 weeks after the institution of treatment. IL-10 levels were determined in the sera and were compared with disease activity, measured using the SLE Disease Activity Index (SLEDAI) and laboratory parameters such as the circulating immune complexes (CIC), C3, C4, anti-DNA antibody, IgG, IgM, and IgA. RESULTS: The IL-10 levels in SLE patients were significantly higher than those of controls (mean +/- SE, 29.2 +/- 6.8 vs. 3.5 +/- 0.6 pg/ml, p < 0.01). Elevated IL-10 levels correlated well with the SLEDAI in SLE patients (r = 0.46, p < 0.01), but did not correlate with other laboratory activity indices. The changes in serum IL-10 levels also correlated with the changes in the SLEDAI score during the patients' disease course (r = 0.51, p < 0.01). CONCLUSION: Serum levels of IL-10 are elevated in SLE patients and increased IL-10 correlates well with SLE disease activity. | - |
dc.description.statementOfResponsibility | prohibition | - |
dc.language | English | - |
dc.publisher | Clinical And Experimental Rheumatology S.A.S | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antibodies, Antinuclear/blood | - |
dc.subject.MESH | Antigen-Antibody Complex/blood | - |
dc.subject.MESH | Complement C3/analysis | - |
dc.subject.MESH | Complement C4/analysis | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin A/blood | - |
dc.subject.MESH | Immunoglobulin G/blood | - |
dc.subject.MESH | Immunoglobulin M/blood | - |
dc.subject.MESH | Interleukin-10/blood* | - |
dc.subject.MESH | Lupus Erythematosus, Systemic/blood | - |
dc.subject.MESH | Lupus Erythematosus, Systemic/immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.title | Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Yong Park | - |
dc.contributor.googleauthor | Sang Kwon Lee | - |
dc.contributor.googleauthor | Dea Sik Kim | - |
dc.contributor.googleauthor | Jang Ho Lee | - |
dc.contributor.googleauthor | Chang H. Lee | - |
dc.contributor.googleauthor | Chan Ho Song | - |
dc.contributor.localId | A00405 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02071 | - |
dc.contributor.localId | A02889 | - |
dc.relation.journalcode | J00555 | - |
dc.identifier.eissn | 1593-098X | - |
dc.identifier.pmid | 9631750 | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.affiliatedAuthor | 김동수 | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 송창호 | - |
dc.contributor.affiliatedAuthor | 이수곤 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 283 | - |
dc.citation.endPage | 288 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.16(3) : 283-288, 1998 | - |
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