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C형 간염바이러스 혈청형과 HCV RNA 정량적 분석

Other Titles
 HCV Serotypes and HCV RNA Quantitation 
Authors
 김영아  ;  김현숙  ;  한광협 
Citation
 Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.18(2) : 259-264, 1998 
Journal Title
 Korean Journal of Clinical Pathology (대한임상병리학회지) 
ISSN
 1015-6445 
Issue Date
1998
Abstract
Background :There are several serological subtypes (serotypes) of hepatitis C virus (HCV) which can be detected by a serological enzyme immunoassay (EIA) method which detects the HCV subtype-specific antibodies against the NS4 legion of the virus. We determined the HCV serotypes chronic HCV infected patients in terms of clinical applications. Method :Subtypes based on Simmonds` classification were detected in chronic HCV patients serologically and viral loads quantitated with branched DNA (bDNA) assay. The EIA was compared with multiplex PCR method. Result :The serotype 1 (Simmonds` classification, 1a, 1b, 1c), the most prevalent form in Korea followed by serotype 2 (Simmonds` classification,2a,2b,2c). The distribution of serotypes and HCV viral loads were not different according to disease severity The patients infected with serotype 1 had higher viremic level (serotype 1, 7.4 ±155 MEq/mL; serotype 2, 1.1±2.2 MEB/mL, P=0.017). The serotype matched with the genotype in 85.7% (18/21) of cases. Conclusion :HCV serotype 1 is the most prevalent form in Korea and seemed to be able to more actively replicate than serotype 2. Both multiplex PCR and EIA can be used for detecting HCV subtypes and mutually interpretable.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177022
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