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Menstrual state should be considered in determining sero-positivity of soluble angiogenic factors in breast cancer.

Authors
 H C Chung  ;  S Y Rha  ;  J B Ahn  ;  K Y Shim  ;  N C Yoo  ;  J H Kim  ;  J K Roh  ;  K S Lee  ;  J S Min  ;  B S Kim  ;  J J Kim 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol.2(4) : 465-470, 1998 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 
ISSN
 0261-8028 
Issue Date
1998
MeSH
Adult ; Aged ; Angiogenesis Inducing Agents/metabolism* ; Breast Neoplasms/metabolism* ; Female ; Fibroblast Growth Factor 2/blood* ; Follicular Phase/metabolism ; Humans ; Luteal Phase/metabolism ; Male ; Menstrual Cycle/metabolism* ; Middle Aged ; Platelet-Derived Growth Factor/metabolism* ; Postmenopause/metabolism ; Premenopause/metabolism ; Reference Values ; Ribonuclease, Pancreatic/blood* ; Vascular Endothelial Growth Factor A/blood*
Abstract
We investigated whether blood angiogenic factor (vascular endothelial growth factor, VEGF; angiogenin; basic fibroblast growth factor, bFGF; platelet-derived growth factor-AB, PDGF-AB) levels change during menstrual cycle of healthy premenopausal females or after menopause. We also measured the serum angiogenic factor levels in 34 operable breast cancer patients and compared them to those of healthy volunteer controls. No differences in the four angiogenic factor levels were found between the follicular and luteal phases of normal menstruation. However, angiogenin and bFGF levels were higher in pre-menopausal females than post-menopausal female and young male healthy volunteers. In cancer patients, the sero-positivity rate of the bFGF was 8.8% with menstrual-state-unmatched cut-off points, which increased to 36.4% with menstrual-state-matched cut-off points. This discrepancy was especially high in post-menopausal cancer patients. In conclusion, physiological elevation of the bFGF during normal menstruation can influence the precise interpretation of the pathological elevation of the bFGF in pre-menopausal breast cancer patients.
Full Text
http://www.spandidos-publications.com/ijmm/2/4/465
DOI
10.3892/ijmm.2.4.465
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Yoo, Nae Choon(유내춘)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176999
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