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Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide.

Authors
 Do Hoon Kim  ;  Jun Sub Jung  ;  Hong Won Suh  ;  Sung Oh Huh  ;  Sung-Kil Min  ;  Bong Ki Son  ;  Jung Hill Park  ;  Nak Doo Kim  ;  Yung Hi Kim  ;  Dong Keun Song 
Citation
 NEUROREPORT, Vol.9(4) : 2261-2264, 1998 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
1998
MeSH
Animals ; Central Nervous System Agents/administration & dosage ; Central Nervous System Agents/pharmacology* ; Corticosterone/blood* ; Enzyme Inhibitors/pharmacology ; Ginsenosides ; Injections, Intraventricular ; Male ; Mice ; Mice, Inbred ICR ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/physiology* ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase Type I ; Saponins/administration & dosage ; Saponins/pharmacology* ; Stress, Psychological/blood*
Abstract
Ginseng total saponins (GTS) injected intracerebroventricularly (i.c.v.) at doses of 0.1-1 microg inhibited the i.c.v. injection stress-induced plasma corticosterone levels in mice. The inhibitory action of GTS was blocked by co-administered N(G)-nitro-L-arginine methyl ester (L-NAME; 1.5 microg, i.c.v.), an inhibitor of nitric oxide synthase (NOS). Of the ginsenosides Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, 20(S)-Rg3 and 20(R)-Rg3 injected i.c.v. at doses of 0.01-1 microg, 20(S)-Rg3 and Rc significantly inhibited the i.c.v. injection stress-induced plasma corticosterone levels. The inhibitory actions of 20(S)-Rg3 and Rc were blocked by co-administered L-NAME (1.5 microg, i.c.v.). These results suggest that GTS, 20(S)-Rg3 and Rc may inhibit the i.c.v. injection stress-induced hypothalamo-pituitary-adrenal response by inducing NO production in the brain.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-199807130-00021&LSLINK=80&D=ovft
DOI
10.1097/00001756-199807130-00021
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Min, Sung Kil(민성길)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176994
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